H-089
1α,25-Dihydroxyvitamin D3 solution
5 μg/mL in ethanol, ampule of 1 mL, certified reference material, Cerilliant®
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A propos de cet article
Formule empirique (notation de Hill) :
C27H44O3
Numéro CAS:
Poids moléculaire :
416.64
NACRES:
NA.24
UNSPSC Code:
41116107
EC Number:
200-578-6
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certified reference material
Quality Level
form
liquid
feature
Snap-N-Spike®/Snap-N-Shoot®
packaging
ampule of 1 mL
manufacturer/tradename
Cerilliant®
concentration
5 μg/mL in ethanol
application(s)
clinical testing
format
single component solution
storage temp.
−70°C
SMILES string
CC(CCCC(C)(C)O)C1CCC2C(\CCCC12C)=C\C=C3\CC(O)CC(O)C3=C
InChI
1S/C27H44O3/c1-18(8-6-14-26(3,4)30)23-12-13-24-20(9-7-15-27(23,24)5)10-11-21-16-22(28)17-25(29)19(21)2/h10-11,18,22-25,28-30H,2,6-9,12-17H2,1,3-5H3/b20-10+,21-11-
InChI key
GMRQFYUYWCNGIN-KWJBEKLWSA-N
General description
1α,25-Dihydroxyvitamin D3 is a biologically active form of vitamin D3 in calcium absorption and deposition. It has widespread effects on cellular differentiation and proliferation, and can modulate immune responsiveness, and central nervous system function. Recent studies suggest that 1α,25-dihydroxyvitamin D3 acts as a chemopreventive agent against several malignancies including cancers of the prostate and colon and shows synergy with other anticancer compounds.
A Certified Spiking Solution® suitable for critical quantitative applications in research and clinical environments including: for use in preparation of controls and calibrators for LC/UV and LC-MS/MS Vitamin D assays; as system tuning/suitability standards; linearity verification; internal proficiency testing; and for OEM use in preparation of reagents, development of assays and instrument IQ/OQ. The stable, quantitative solution format provides significant benefits to the user including material savings, increased efficiency of labor, and convenience of use. The shelf stable Snap-N-Spike® format allows laboratories to eliminate painstaking weighing operations and provides the ability to spike a known concentration of analyte into their matrix of choice just before use.
Application
1α,25-Dihydroxyvitamin D3 may be used as a certified reference material for the determination of the analyte in biological fluids by liquid chromatography-tandem mass spectrometry.
Legal Information
CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany
signalword
Danger
hcodes
Hazard Classifications
Eye Irrit. 2 - Flam. Liq. 2
Classe de stockage
3 - Flammable liquids
wgk
WGK 1
flash_point_f
57.2 °F - closed cup
flash_point_c
14 °C - closed cup
Certificats d'analyse (COA)
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Sensitive analysis of 1?, 25-dihydroxyvitamin D3 in biological fluids by liquid chromatography--tandem mass spectrometry
Kissmeyer AM and Sonne K
Journal of Chromatography A, 935(1-2), 93-103 (2001)
Determination of 1, 25-dihydroxyvitamin D2 and 1, 25-dihydroxyvitamin D3 in human serum using liquid chromatography with tandem mass spectrometry
Fang H, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 1027, 19-26 (2016)
Zhican Wang et al.
Analytical biochemistry, 418(1), 126-133 (2011-07-26)
Simultaneous and accurate measurement of circulating vitamin D metabolites is critical to studies of the metabolic regulation of vitamin D and its impact on health and disease. To that end, we have developed a specific liquid chromatography-tandem mass spectrometry (LC-MS/MS)