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Merck

I-902

Imipramine hydrochloride solution

1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®

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A propos de cet article

Formule empirique (notation de Hill) :
C19H24N2 · HCl
Numéro CAS:
113-52-0
Poids moléculaire :
316.87
NACRES:
NA.24
UNSPSC Code:
41116107
EC Number:
200-659-6

Principaux documents

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InChI key

XZZXIYZZBJDEEP-UHFFFAOYSA-N

InChI

1S/C19H24N2.ClH/c1-20(2)14-7-15-21-18-10-5-3-8-16(18)12-13-17-9-4-6-11-19(17)21;/h3-6,8-11H,7,12-15H2,1-2H3;1H

SMILES string

Cl.CN(C)CCCN1c2ccccc2CCc3ccccc13

grade

certified reference material

form

liquid

feature

Snap-N-Spike®/Snap-N-Shoot®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

concentration

1.0 mg/mL in methanol (as free base)

technique(s)

gas chromatography (GC): suitable, liquid chromatography (LC): suitable

application(s)

clinical testing

format

single component solution

storage temp.

2-8°C

Quality Level

300

Gene Information

human ... SLC6A2(6530), SLC6A4(6532)

Catégories apparentées

General description

Imipramine, also known as melipramine, is a tricyclic antidepressant prescribed for the treatment of major depression, enuresis, and anxiety disorder. This certified solution standard is suitable for use in forensic analysis, clinical toxicology, or urine drug testing applications by LC-MS/MS or GC/MS. Imipramine is marketed under the trade name Tofranil.

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

target_organs

Eyes,Central nervous system

Classe de stockage

3 - Flammable liquids

wgk

WGK 2

flash_point_f

49.5 °F - closed cup

flash_point_c

9.7 °C - closed cup

Certificats d'analyse (COA)

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Tatyana Strekalova et al.
Behavioural brain research, 245, 101-106 (2013-02-26)
Tricyclics and selective serotonin reuptake inhibitors (SSRIs) are probably the most widely employed reference antidepressants in animal studies on depression. Using imipramine and citalopram, we sought to assess which drug would be more appropriate as pharmacological reference in paradigms of
Indrek Saar et al.
Journal of neurochemistry, 127(1), 114-123 (2013-04-23)
Neuropeptide galanin and its three G-protein coupled receptors, galanin receptor type 1-galanin receptor type 3 (GalR1-GalR3), are involved in the regulation of numerous physiological and disease processes, and thus represent tremendous potential in neuroscience research and novel drug lead development.
D J Hines et al.
Translational psychiatry, 3, e212-e212 (2013-01-17)
Major depressive disorder is a debilitating condition with a lifetime risk of ten percent. Most treatments take several weeks to achieve clinical efficacy, limiting the ability to bring instant relief needed in psychiatric emergencies. One intervention that rapidly alleviates depressive
Fenghua Chen et al.
Synapse (New York, N.Y.), 67(3), 127-134 (2012-11-16)
Depressive disorders and the treatment thereof have been associated with a number of neuroplastic events, such as neurogenesis and synaptic remodeling in discrete areas of the brain. The associations of these events in changes regarding the energy supply have not
Ute Krügel et al.
Journal of psychiatric research, 47(5), 611-616 (2013-02-12)
Pro-inflammatory cytokines such as tumour necrosis factor-alpha (TNF-α) have repeatedly been shown to play a pivotal role in the pathophysiology of depression. Therefore, we tested the possible antidepressant-like effect of the anti-TNF-α drug etanercept in an animal model of chronic
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