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Merck

V-019

Vitamine B12

1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

Synonyme(s) :

α-(5,6-Diméthylbenzimidazolyl)cyanocobamide, CN-Cbl, Cyanocob(III)alamine, Cyanocobalamine

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A propos de cet article

Formule empirique (notation de Hill) :
C63H88CoN14O14P
Numéro CAS:
68-19-9
Poids moléculaire :
1355.37
NACRES:
NA.24
PubChem Substance ID:
329828962
UNSPSC Code:
41116107
EC Number:
200-659-6
Beilstein/REAXYS Number:
4122889

Principaux documents

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InChI key

RMRCNWBMXRMIRW-QJRSUKKJSA-L

InChI

1S/C62H90N13O14P.CN.Co/c1-29-20-39-40(21-30(29)2)75(28-70-39)57-52(84)53(41(27-76)87-57)89-90(85,86)88-31(3)26-69-49(83)18-19-59(8)37(22-46(66)80)56-62(11)61(10,25-48(68)82)36(14-17-45(65)79)51(74-62)33(5)55-60(9,24-47(67)81)34(12-15-43(63)77)38(71-55)23-42-58(6,7)35(13-16-44(64)78)50(72-42)32(4)54(59)73-56;1-2;/h20-21,23,28,31,34-37,41,52-53,56-57,76,84H,12-19,22,24-27H2,1-11H3,(H15,63,64,65,66,67,68,69,71,72,73,74,77,78,79,80,81,82,83,85,86);;/q;;+2/p-2/t31-,34-,35-,36-,37+,41-,52-,53-,56-,57?,59-,60+,61+,62+;;/m1../s1

SMILES string

C/C(C1=N[C@]([C@]([C@H](CC(N)=O)[C@@]/2(C)CCC(NC[C@@H](OP([O-])(O[C@H]3[C@@H](O)[C@@H](N4C=[N]5C6=C4C=C(C)C(C)=C6)O[C@@H]3CO)=O)C)=O)([H])N([Co+]5C#N)C2=C(C)/C([C@@H](CCC(N)=O)C/7(C)C)=NC7=C/8)(C)[C@@](C)(CC(N)=O)[C@@H]1CCC(N)=O)=C9N=C8[C@@H](CCC(N)=O)[C@

grade

certified reference material

form

liquid

feature

Snap-N-Spike®/Snap-N-Shoot®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

concentration

1.0 mg/mL in methanol

technique(s)

gas chromatography (GC): suitable, liquid chromatography (LC): suitable

application(s)

clinical testing
clinical testing

format

single component solution

storage temp.

−20°C

Quality Level

300

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Catégories apparentées

General description

Cyanocobalamin is the most common and widely-produced of the vitamin B12 analogs. Vitamin B12, important for proper neuronal function and formation of blood cellular components, is monitored directly in patient serum samples by LC-MS/MS.

Application

This certified solution standard is suitable for use as a starting material in the preparation of linearity standards, calibrators or controls in a variety of testing applications from diagnostic testing of vitamin B12 deficiency by LC-MS/MS to quality control testing of vitamin B12-based dietary supplements/fortified foods or pharmaceutical preparations.

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

target_organs

Eyes

Classe de stockage

3 - Flammable liquids

wgk

WGK 1

flash_point_f

49.5 °F - closed cup

flash_point_c

9.7 °C - closed cup

Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

Hossein Khedmat et al.
Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia, 24(4), 759-763 (2013-07-03)
Helicobacter pylori (HP) is a common infection worldwide and has been associated with severe morbidity. The level of vitamin B 12 in HP-infected chronic kidney disease (CKD) patients is reported to be lower than in the general population. The present
Spinal injection therapy for low back pain.
J Bart Staal et al.
JAMA, 309(23), 2439-2440 (2013-05-18)
Reversible disconnection syndrome: an unusual presentation of vitamin B12 deficiency.
Rajesh Verma et al.
Neurology India, 61(2), 167-169 (2013-05-07)
Christine M Armour et al.
Pediatrics, 132(1), e257-e261 (2013-06-19)
A neonate, who was found to have an elevated C3/C2 ratio and minimally elevated propionylcarnitine on newborn screening, was subsequently identified as having the rare cblF inborn error of vitamin B12 (cobalamin) metabolism. This disorder is characterized by the retention
Sabina Lutz et al.
Journal of the American Animal Hospital Association, 49(3), 197-203 (2013-03-29)
Juvenile cobalamin deficiency is a rare disease in border collies and its diagnosis requires a high level of clinical suspicion. The goal of this study was to increase awareness of this disease by describing the clinical and laboratory findings in
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