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Merck

12-151

PKA Inhibitor Peptide

lyophilized powder, for Neuroscience applications

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A propos de cet article

UNSPSC Code:
12352202
eCl@ss:
32160405
NACRES:
NA.41

Principaux documents

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Nom du produit

PKA Inhibitor peptide, The PKA Inhibitor peptide controls the biological activity of PKA. This small molecule/inhibitor is primarily used for Neuroscience applications.

form

lyophilized powder

manufacturer/tradename

Upstate®

technique(s)

activity assay: suitable (kinase)

NCBI accession no.

NM_002730.3, NM_207518.1

UniProt accession no.

P17612

shipped in

wet ice

Quality Level

100

Biochem/physiol Actions

Protein Target: PKA
Target Sub-Family: AGC

Physical form

Lyophilized powder (from H2O)

Preparation Note

Lyophilized: Stable for 2 years at -20°C . Rehydrated: Stable for 1 year at -20°C.

Analysis Note

Routinely evaluated by inhibition of PKA catalytic subunit (14-114).

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Classe de stockage

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificats d'analyse (COA)

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Y I Lee et al.
The Journal of biological chemistry, 276(20), 16969-16977 (2001-03-30)
The hepatitis B virus-X (HBx) protein is known as a multifunctional protein that not only coactivates transcription of viral and cellular genes but coordinates the balance between proliferation and programmed cell death, by inducing or blocking apoptosis. In this study
Heterogeneity in beta-adrenergic receptor kinase expression in the lung accounts for cell-specific desensitization of the beta2-adrenergic receptor
McGraw, D. W. and Liggett, S. B.
The Journal of Biological Chemistry, 272, 7338-7344 (1997)
H L Lai et al.
The Journal of biological chemistry, 272(8), 4970-4977 (1997-02-21)
We have previously reported that phosphorylation of adenylyl cyclase type VI (AC6) may result in the suppression of adenylyl cyclase activity during desensitization of the A2a-adenosine receptor-mediated cAMP response (A2a desensitization) in rat pheochromocytoma PC12 cells. In the present study
Primary structural determinants essential for potent inhibition of cAMP-dependent protein kinase by inhibitory peptides corresponding to the active portion of the heat-stable inhibitor protein.
Glass, D B, et al.
The Journal of Biological Chemistry, 264, 8802-8810 (1989)
Christian M Smolko et al.
Scientific reports, 9(1), 19409-19409 (2019-12-21)
Protein kinases are enzymes whose abundance, protein-protein interactions, and posttranslational modifications together determine net signaling activity in cells. Large-scale data on cellular kinase activity are limited, because existing assays are cumbersome, poorly sensitive, low throughput, and restricted to measuring one

Numéro d'article de commerce international

RéférenceGTIN
12-15104053252333507

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