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264103

Désoxycholate de sodium

Name: Désoxycholate de sodium
Brand: MM

ULTROL^® Grade, ≥99% (TLC), detergent to solubilize membrane-bound proteins in their native state

Synonyme(s) :

Acide 3α,12α-dihydroxy-5β-cholanique sodium salt, Acide 7-désoxycholique sodium salt, Acide désoxycholique sodium salt

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A propos de cet article

Formule empirique (notation de Hill) :

C₂₄H₃₉NaO₄

Numéro CAS:

302-95-4

Poids moléculaire :

414.55

NACRES:

NA.21

UNSPSC Code:

12161902

Beilstein/REAXYS Number:

3581950

MDL number:

MFCD00064139

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Propriétés

description

Merck USA index - 14, 2899

Quality Level

100

assay

≥99% (TLC)

form

solid

mol wt

micellar avg mol wt 1200-5000, micellar wt 1200-4900

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, desiccated (hygroscopic)

aggregation number

3 - 12, 3-12

color

white

pKa

6.2

CMC

2 - 6 mM, 2-6 mM (20-25°C)

HLB

shipped in

ambient

storage temp.

15-25°C

SMILES string

[Na+].[H][C@]12CC[C@@]3([H])[C@]4([H])CC[C@H]([C@H](C)CCC([O-])=O)[C@@]4(C)[C@@H](O)C[C@]3([H])[C@@]1(C)CC[C@@H](O)C2

InChI

1S/C24H40O4.Na/c1-14(4-9-22(27)28)18-7-8-19-17-6-5-15-12-16(25)10-11-23(15,2)20(17)13-21(26)24(18,19)3;/h14-21,25-26H,4-13H2,1-3H3,(H,27,28);/q;+1/p-1/t14-,15-,16-,17+,18-,19+,20+,21+,23+,24-;/m1./s1

InChI key

FHHPUSMSKHSNKW-SMOYURAASA-M

Description

General description

Absorbance (10%, H₂O, 290 nm):≤0.25.

Highly purified and intended for use as a detergent to solubilize membrane-bound proteins in their native state (absorbance: <0.25 at 290 nm, 10% H₂O; aggregation number: 3-12; CMC: 2-6 mM; micellar weight: 1200-4900; pK_a: 6.2). Reported to induce tyrosine phosphorylation of β-catenin and its subsequent translocation to the nucleus, promoting activation of β-catenin signaling (effective concentration 5-50 µM).

Application

Treatment of mucocutaneous leishmaniasis - A systematic review.: Sodium deoxycholate is discussed in this systematic review as a component in treatment regimens for mucocutaneous leishmaniasis, offering comprehensive insights into current therapeutic approaches and outcomes (Fischer et al., 2024).

Preparation Note

Do not use with Mn²⁺ in solution.

Following reconstitution, refrigerate (4°C). Stock solutions are stable for up to 6 months at 4°C. Discard if bacterial or fungal growth is observed.

Other Notes

Pai, R., et al. Mol. Biol. Cell15, 2156.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

ULTROL is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Harmful (C)

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pictograms

GHS07

signalword

Warning

hcodes

H302

pcodes

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

Classe de stockage

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c