LY 294002

Name: LY 294002
Brand: MM

InSolution, ≥98%, 10 mM, reversible and specific inhibitor of PI 3-kinase

Synonyme(s) :

InSolution LY 294002, 2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one, BRD2 Inhibitor IV, BRD3 Inhibitor III, BRD4 Inhibitor IV

Se connecterpour consulter vos tarifs contractuels et ceux de votre entreprise/organisme

Sélectionner une taille de conditionnement

Toutes les photos(1)

About This Item

Formule empirique (notation de Hill) :

C₁₉H₁₇NO₃

Numéro CAS:

154447-36-6

Poids moléculaire :

307.34

Numéro MDL:

MFCD00270881

Code UNSPSC :

12352200

Nomenclature NACRES :

NA.77

Niveau de qualité

100

Essai

≥98% (HPLC)

Forme

liquid

Fabricant/nom de marque

Calbiochem^®

Conditions de stockage

OK to freeze
protect from light

Conditions d'expédition

wet ice

Température de stockage

−20°C

Chaîne SMILES

N4(CCOCC4)c1[o]c2c([c](c1)=O)cccc2c3ccccc3

InChI

1S/C19H17NO3/c21-17-13-18(20-9-11-22-12-10-20)23-19-15(7-4-8-16(17)19)14-5-2-1-3-6-14/h1-8,13H,9-12H2

Clé InChI

CZQHHVNHHHRRDU-UHFFFAOYSA-N

Catégories apparentées

Bioactive Small Molecule Inhibitors

Actions biochimiques/physiologiques

Cell permeable: yes

Primary Target
phosphatidylinositol 3-kinase

Product competes with ATP.

Reversible: yes

Target IC₅₀: 1.4 µM against phosphatidylinositol 3-kinase

Conditionnement

Packaged under inert gas

Forme physique

A 10 mM (1 mg/325 µl) solution of LY 294002 (Cat. No. 440202) in DMSO.

Notes préparatoires

Following initial thaw, aliquot and freeze (-20°C).

Autres remarques

Dittman, A., et al. 2013. ACS Chem. Biol.9, 495.
Baumann, P., and West, S.C. 1998. Proc. Natl. Acad. Sci. USA95, 14066.
Cardone, M.H., et al. 1998. Science282, 1318.
Vlahos, C.J., et al. 1995. J. Immunol.154, 2413.
Yano, H., et al. 1995. Biochem. J.312, 145.
Vlahos, C.J., et al. 1994. J. Biol. Chem.269, 5241.

Selected Citations
Lee, J., et al. 2009. Cell Stem Cell5, 76.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Clause de non-responsabilité

Toxicity: Irritant (B)

Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

188.6 °F - (refers to pure substance)

Point d'éclair (°C)

87 °C - (refers to pure substance)

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

Déjà en possession de ce produit ?

Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Cytoprotection against Oxidative Stress by Methylnissolin-3-O-β-d-glucopyranoside from Astragalus membranaceus Mainly via the Activation of the Nrf2/HO-1 Pathway.

Xiaohua Wu et al.

Molecules (Basel, Switzerland), 26(13) (2021-07-03)

Astragalus membranaceus is a famous herb found among medicinal and food plants in East and Southeastern Asia. The Nrf2-ARE assay-guided separation of an extract from Jing liqueur led to the identification of a nontoxic Nrf2 activator, methylnissolin-3-O-β-d-glucopyranoside (MNG, a component

Studying the subcellular localization and DNA-binding activity of FoxO transcription factors, downstream effectors of PI3K/Akt.

Abdelkader Essafi et al.

Methods in molecular biology (Clifton, N.J.), 462, 201-211 (2009-01-24)

This chapter describes methods for studying downstream events of the PI3K/Akt signaling cascade, focusing on the FoxO transcription factors. These approaches also represent alternative means for gauging the phosphoinositide-3 kinase/Akt activity. We describe protocols for the fractionation of cytoplasmic and

Augmented lipopolysaccharide-induced TNF-alpha production by peritoneal macrophages in type 2 diabetic mice is dependent on elevated glucose and requires p38 MAPK.

Christina L Sherry et al.

Journal of immunology (Baltimore, Md. : 1950), 178(2), 663-670 (2007-01-05)

Dysregulated inflammation is a complication of type 2 diabetes (T2D). In this study, we show that augmented LPS-induced TNF-alpha production by resident peritoneal macrophages (PerMphi) in type 2 diabetic (db/db) mice is dependent on elevated glucose and requires p38 MAPK.

Schlafen 11 expression in human acute leukemia cells with gain-of-function mutations in the interferon-JAK signaling pathway.

Yasuhisa Murai et al.

iScience, 24(10), 103173-103173 (2021-10-26)

Schlafen11 (SLFN11) is referred to as interferon (IFN)-inducible. Based on cancer genomic databases, we identified human acute myeloid and lymphoblastic leukemia cells with gain-of-function mutations in the Janus kinase (JAK) family as exhibiting high SLFN11 expression. In these cells, the

Suppression of HSV-1 infection and viral reactivation by CRISPR-Cas9 gene editing in 2D and 3D culture models.

Anna Bellizzi et al.

Molecular therapy. Nucleic acids, 35(3), 102282-102282 (2024-08-23)

Although our understanding of herpes simplex virus type 1 (HSV-1) biology has been considerably enhanced, developing therapeutic strategies to eliminate HSV-1 in latently infected individuals remains a public health concern. Current antiviral drugs used for the treatment of HSV-1 complications

Afficher tous les articles scientifiques apparentés

Contenu apparenté

PRODUCTO REGULADO POR LA SAGARPA

CARTA DE USO GENERAL 2016

()

PRODUCTO REGULADO POR LA SECRETARÍA DE SALUD

Notre équipe de scientifiques dispose d'une expérience dans tous les secteurs de la recherche, notamment en sciences de la vie, science des matériaux, synthèse chimique, chromatographie, analyse et dans de nombreux autres domaines..

Contacter notre Service technique