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557303

Rifampicin

≥97% (HPLC), powder (or crystals), RNA polymerase inhibitor, Calbiochem®

Synonyme(s) :

Rifampicin, Rifampin, 3-(4-Methylpiperazinyliminomethyl)rifamycin SV

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A propos de cet article

Formule empirique (notation de Hill) :
C43H58N4O12
Numéro CAS:
13292-46-1
Poids moléculaire :
822.94
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD00151389
Assay:
~97-102% (by Assay)
Form:
powder (or crystals)
Quality level:
100
Storage condition:
OK to freeze
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Nom du produit

Rifampicin, Antibiotic that specifically inhibits DNA-dependent RNA polymerase in bacteria by forming an inactive complex.

Quality Level

100

assay

~97-102% (by Assay)

form

powder (or crystals)

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

red-brown

shipped in

ambient

storage temp.

−20°C

SMILES string

N5(CCN(CC5)C)\N=C\c1c2c(c3c(c4c(c(c3O)C)O[C@](O\C=C\[C@@H]([C@H]([C@H]([C@@H]([C@@H]([C@@H]([C@H]([C@H](\C=C\C=C(/C(=O)N2)\C)C)O)C)O)C)OC(=O)C)C)OC)(C4=O)C)c1O)O

InChI

1S/C43H58N4O12/c1-21-12-11-13-22(2)42(55)45-33-28(20-44-47-17-15-46(9)16-18-47)37(52)30-31(38(33)53)36(51)26(6)40-32(30)41(54)43(8,59-40)57-19-14-29(56-10)23(3)39(58-27(7)48)25(5)35(50)24(4)34(21)49/h11-14,19-21,23-25,29,34-35,39,49-53H,15-18H2,1-10H3,(H,45,55)/b12-11+,19-14+,22-13-,44-20+/t21-,23+,24+,25+,29-,34-,35+,39+,43-/m0/s1

InChI key

JQXXHWHPUNPDRT-WLSIYKJHSA-N

General description

Antibiotic that specifically inhibits DNA-dependent bacterial RNA polymerase by forming an inactive complex with RNA polymerase. Does not affect mammalian RNA polymerase. Inhibits transcription by preventing the initial transcription complex from entering the elongation mode.

Biochem/physiol Actions

Primary Target
DNA-dependent RNA polymerase in bacteria

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 2 months at -20°C.

Other Notes

Jin, D.J. and Turnbough, Jr., C.L. 1994. J. Mol. Biol. 236, 72.
Levin, M.E. and Hatfull, G.F. 1993. Mol. Microbiol. 8, 277.
Wehrli, W., et al. 1968. Proc. Natl. Acad. Sci. USA61, 667.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Harmful & Carcinogenic / Teratogenic (E)

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pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Classe de stockage

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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