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Merck

AB1570W

Anti-GABA Transporter-1 Antibody

Chemicon®, from rabbit

Synonyme(s) :

GAT-1

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A propos de cet article

UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IHC, WB
Citations:
19

Principaux documents

Voir toute la documentation
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biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

rabbit, mouse, monkey, human, rat, feline

manufacturer/tradename

Chemicon®

technique(s)

immunohistochemistry: suitable, western blot: suitable

NCBI accession no.

NM_003042.2

UniProt accession no.

P30531

shipped in

wet ice

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... SLC6A1(6529)

General description

67 kDa

Immunogen

Rat GAT-1, C-terminus (aa 588-599)

Application

Anti-GABA Transporter-1 Antibody detects level of GABA Transporter-1 & has been published & validated for use in IH & WB.
Western blotting: 1:200-1:500 (67 kDa)

Immunohistochemistry

Optimal working dilutions must be determined by the end user.

Biochem/physiol Actions

Recognizes GABA Transporter-1 (GAT-1), C-terminus. No cross-reactivity to the C-termini of other transmitter transporters detected.

Physical form

Affinity Purified antibody. Lyophilized from 0.1 M PBS with 1% BSA and 0.1% sodium azide. Reconstitute with 100 μL of sterile distilled water.

Preparation Note

Maintain lyophilized material at 2–8°C for up to 12 months. Maintain reconstituted materialat -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

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pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Aquatic Chronic 3

Classe de stockage

11 - Combustible Solids

wgk

WGK 3

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Roberta Celli et al.
Neuropharmacology, 178, 108240-108240 (2020-08-10)
Previous studies have shown that injection of the mGlu5 receptor positive allosteric modulator (PAM) VU0360172 into either the thalamus or somatosensory cortex markedly reduces the frequency of spike-and-wave discharges (SWDs) in the WAG/Rij model of absence epilepsy. Here we have
Roberta Celli et al.
Current neuropharmacology, 21(1), 105-118 (2022-05-18)
Previous studies suggest that different metabotropic glutamate (mGlu) receptor subtypes are potential drug targets for treating absence epilepsy. However, no information is available on mGlu3 receptors. To examine whether (i) changes of mGlu3 receptor expression/signaling are found in the somatosensory
Brain-derived neurotrophic factor (BDNF) enhances GABA transport by modulating the trafficking of GABA transporter-1 (GAT-1) from the plasma membrane of rat cortical astrocytes.
Vaz, SH; J?rgensen, TN; Cristov?o-Ferreira, S; Duflot, S; Ribeiro, JA; Gether, U; Sebasti?o, AM
The Journal of Biological Chemistry null
Elena E Bagley et al.
Neuron, 45(3), 433-445 (2005-02-08)
Adaptations in neurons of the midbrain periaqueductal gray (PAG) induced by chronic morphine treatment mediate expression of many signs of opioid withdrawal. The abnormally elevated action potential rate of opioid-sensitive PAG neurons is a likely cellular mechanism for withdrawal expression.
Diana Martinez et al.
Frontiers in physiology, 12, 821110-821110 (2022-02-01)
The brainstem nucleus tractus solitarii (nTS) processes and modulates the afferent arc of critical peripheral cardiorespiratory reflexes. Sensory afferents release glutamate to initiate the central component of these reflexes, and glutamate concentration is critically controlled by its removal via astrocytic
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Numéro d'article de commerce international

RéférenceGTIN
AB1570W04053252274961

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