AB1593
Anti-Amyloid Precursor Protein (APP) Antibody
CHEMICON®, goat polyclonal
Synonyme(s) :
APP
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A propos de cet article
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Clone:
polyclonal
Species reactivity:
human
Application:
ELISA, IF, IHC (p), WB
Citations:
2
Service technique
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Anti-Amyloid Precursor Protein Antibody, a.a. 44-63, serum, Chemicon®
biological source
goat
Quality Level
antibody form
serum
antibody product type
primary antibodies
clone
polyclonal
species reactivity
human
manufacturer/tradename
Chemicon®
technique(s)
ELISA: suitable, immunofluorescence: suitable, immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable, western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
unmodified
Gene Information
human ... APP(351)
Immunogen
Epitope: a.a. 44-63
Peptide to the N-terminal region (amino acids 44-63) of the APP protein.
Application
Anti-Amyloid Precursor Protein Antibody, a.a. 44-63 is an antibody against Amyloid Precursor Protein for use in ELISA, IF, WB, IH, IH(P).
Immunoblotting: 1:1,000
Immunofluorescence
Immunohistochemistry
Formalin fixed paraffin embedded tissue:1:50-1:100
4% paraformaldehyde fixed frozen sections: 1:2,500-1:5,000
ELISA: 1:1,500 against immunogen peptide
Optimal working dilutions must be determined by end user.
Immunofluorescence
Immunohistochemistry
Formalin fixed paraffin embedded tissue:1:50-1:100
4% paraformaldehyde fixed frozen sections: 1:2,500-1:5,000
ELISA: 1:1,500 against immunogen peptide
Optimal working dilutions must be determined by end user.
Research Category
Neuroscience
Neuroscience
Research Sub Category
Neurodegenerative Diseases
Neurodegenerative Diseases
Biochem/physiol Actions
Recognizes amyloid precursor protein (APP). In Alzheimer′s disease, this protein is broken down and releases the 12 amino acid b-amyloid protein that is found in senile plaques and vessels.
The amyloid precursor protein is the subject of intensive investigations to determine how this protein is broken down abnormally in Alzheimer′s disease to give rise to the b-amyloid protein which is present in senile plaques and vessels. This antiserum has been shown to be immunoreactive to the immunizing peptide by ELISA. The antiserum will immunolabel dystrophic neurites in senile plaques in both formalin-fixed paraffin sections and paraformaldehyde fixed frozen sections from Alzheimer′s brain.
This antiserum should be a valuable tool for scientist and neuropathologists who study the role of amyloid in Alzheimer′s′s disease.
The amyloid precursor protein is the subject of intensive investigations to determine how this protein is broken down abnormally in Alzheimer′s disease to give rise to the b-amyloid protein which is present in senile plaques and vessels. This antiserum has been shown to be immunoreactive to the immunizing peptide by ELISA. The antiserum will immunolabel dystrophic neurites in senile plaques in both formalin-fixed paraffin sections and paraformaldehyde fixed frozen sections from Alzheimer′s brain.
This antiserum should be a valuable tool for scientist and neuropathologists who study the role of amyloid in Alzheimer′s′s disease.
Physical form
Goat antiserum. Liquid with 0.1% Sodium Azide
Preparation Note
Store at -20ºC in undiluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles.
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Classe de stockage
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificats d'analyse (COA)
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Contenu apparenté
Alzheimer’s Disease: Amyloid Cascade and Beyond Product Focus
Grant T Corbett et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(27), 8445-8450 (2015-06-17)
Amyloid precursor protein (APP) derivative β-amyloid (Aβ) plays an important role in the pathogenesis of Alzheimer's disease (AD). Sequential proteolysis of APP by β-secretase and γ-secretase generates Aβ. Conversely, the α-secretase "a disintegrin and metalloproteinase" 10 (ADAM10) cleaves APP within
Numéro d'article de commerce international
| Référence | GTIN |
|---|---|
| AB1593 | 04053252325915 |