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Merck

MAB2253Z

Anti-Integrin β1 Antibody, clone 6S6, Azide Free

clone 6S6, Chemicon®, from mouse

Synonyme(s) :

CD29

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A propos de cet article

UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Clone:
6S6, monoclonal
Species reactivity:
human
Application:
FACS, IHC, IP
Citations:
22

Principaux documents

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biological source

mouse

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

6S6, monoclonal

species reactivity

human

manufacturer/tradename

Chemicon®

technique(s)

flow cytometry: suitable, immunohistochemistry: suitable, immunoprecipitation (IP): suitable

isotype

IgG1

NCBI accession no.

NM_002292.3

UniProt accession no.

P05556

shipped in

wet ice

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... ITGB1(3688)

Catégories apparentées

General description

88 kDa
Integrin beta 1, also known as CD29, is a 130 kDa transmembrane glycoprotein that forms noncovalent complexes with various Integrin alpha subunits (including alpha 1, alpha 2, alpha 3, alpha 4, alpha 5, and alpha 6) to form the functional receptors that bind to specific extracellular matrix proteins. Integrin receptors are involved in the regulation of a variety of important biological functions, including embryonic development, wound repair, hemostasis, and prevention of programmed cell death. They are also implicated in abnormal pathological states such as tumor directed angiogenesis, tumor cell growth, and metastasis. These heterodimeric receptors bridge the cytoplasmic actin cytoskeleton with proteins present in the extracellular matrix and/or on adjacent cells. Interactions between integrins and the extracellular matrix lead to activation of signal transduction pathways and regulation of gene expression.

Immunogen

Human synovial cells

Application

Anti-Integrin β1 Antibody, clone 6S6, Azide Free detects level of Integrin β1 & has been published & validated for use in FC, IH & IP.
Immunoprecipitation

Immunohistochemistry on frozen sections

Flow cytometry

Blocks adhesion of cells to extracellular matrix proteins

Induces aggregation of certain lymphoid cells

Does not bind reduced beta.1 integrin on Western blot

Optimal working dilutions must be determined by end user.
Research Category
Cell Structure
Research Sub Category
Integrins

Biochem/physiol Actions

Reacts with the human integrin beta1 subunit. Specificity verified by preclearing of beta1in immunoprecipitation, flow cytometry on transfectant cells displaying human beta1 integrin, and reactivity with purified beta1. Similar in behavior and characteristics to antibody clone 3S3 (Wilkins et al., 1996).

Physical form

Format: Purified
Protein A Purified mouse immunoglobulin in PBS, no preservatives.
Protein A purified

Preparation Note

Maintain 6 months at 4°C, from date of shipment. Do not freeze. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Analysis Note

Control
Tonsil, human skin tissue

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Classe de stockage

12 - Non Combustible Liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Francois Lehembre et al.
The EMBO journal, 27(19), 2603-2615 (2008-09-06)
Loss of expression of the cell-cell adhesion molecule E-cadherin is a hallmark of epithelial-mesenchymal transition (EMT) in development and in the progression from epithelial tumours to invasive and metastatic cancers. Here, we demonstrate that the loss of E-cadherin function upregulates
Charles Saby et al.
Oncotarget, 7(18), 24908-24927 (2016-04-29)
Tumor cells are confronted to a type I collagen rich environment which regulates cell proliferation and invasion. Biological aging has been associated with structural changes of type I collagen. Here, we address the effect of collagen aging on cell proliferation
Leah C Abraham et al.
Experimental cell research, 313(5), 1045-1055 (2007-02-06)
The biodegradation of collagen and the deposition of new collagen-based extracellular matrices are of central importance in tissue remodeling and function. Similarly, for collagen-based biomaterials used in tissue engineering, the degradation of collagen scaffolds with accompanying cellular infiltration and generation
Simone Bergmann et al.
Journal of cell science, 122(Pt 2), 256-267 (2009-01-02)
By interacting with components of the human host, including extracellular matrix (ECM) proteins, Streptococcus pneumoniae has evolved various strategies for colonization. Here, we characterized the interaction of pneumococci with the adhesive glycoprotein vitronectin and the contribution of this protein to
Edwin C K Heng et al.
Journal of cellular biochemistry, 98(2), 409-420 (2006-01-28)
CCN2, (connective tissue growth factor, CTGF) is a matricellular factor associated with fibrosis that plays an important role in the production and maintenance of fibrotic lesions. Increased collagen deposition and accumulation is a common feature of fibrotic tissues. The mechanisms
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Contenu apparenté

An Introduction to Antibodies and Their Applications

The 3rd edition of An Introduction to Antibodies and Their Applications provides a concise overview of some of the key features for the use of antibodies and immunochemical techniques in biological research. This handy reference guide supplements the techniques described in literature, recorded in general laboratory procedures, and described on individual product data sheets. Antibody design, development, and production are our expertise. Stringent validation of our antibodies is only one component of a comprehensive process we undertake to provide the antibodies most cited by the research community (see section Antibody Quality on page 2 for an in-depth look at our expertise).

Numéro d'article de commerce international

RéférenceGTIN
MAB2253Z04053252360299

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