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Merck

61188

Losartan Potassium

Synonyme(s) :

2-Butyl-4-chloro-1-{[2′-(1H-tetrazol-5-yl)(1,1′-biphenyl)-4-yl]methyl}-1H-imidazole-5-methanol monopotassium salt

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A propos de cet article

Formule empirique (notation de Hill) :
C22H22ClKN6O
Numéro CAS:
124750-99-8
Poids moléculaire :
461.00
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329759382
MDL number:
MFCD02092704
Beilstein/REAXYS Number:
5845770

Principaux documents

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InChI

1S/C22H22ClN6O.K/c1-2-3-8-20-24-21(23)19(14-30)29(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22-25-27-28-26-22;/h4-7,9-12,30H,2-3,8,13-14H2,1H3;/q-1;+1

SMILES string

CCCCc1nc(Cl)c(CO)n1Cc2ccc(cc2)-c3ccccc3-c4nnnn4[K]

InChI key

OXCMYAYHXIHQOA-UHFFFAOYSA-N

form

powder or crystals

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

impurities

≤0.5% water

application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

Quality Level

200

Gene Information

human ... AGTR1(185)

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Catégories apparentées

Application

Losartan potassium may be used as an analytical reference standard for the quantification of the analyte in the following:
  • Pharmaceutical formulations using reversed-phase high-performance liquid chromatography and UV-spectrophotometric techniques.
  • Rat plasma using liquid chromatography–tandem mass spectrometry (LC–MS/MS) technique.

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

Losartan potassium is an orally available, potent, and selective competitive angiotensin II receptor type 1 (AT1) antagonist. Losartan potassium is used for treatment of hypertension.
orally available, potent, and selective competitive angiotensin II receptor type 1 (AT1) antagonist

General description

Losartan potassium has long lasting effects, and its efficacy is generally increased, when combined with the diuretic co-active hydrochlorothiazide.
Losartan potassium is an antihypertensive drug that is found to be an angiotensin II receptor type 1 blocker. It finds applications in reducing mechanical stress thereby having a control over the condition of cardiac hypertrophy.

Other Notes

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Classe de stockage

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificats d'analyse (COA)

Lot/Batch Number
0000525084
0000525084
0000401300
0000401300
0000336842

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  4. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  5. What class of compound is Losartan Potassium, Product 61188?

    Losartan is an angiotensin II receptor antagonist that is used to treat hypertension.  It has imidazole, tetrazole, and benzene rings as part of its structure. It is anionic at neutral pH; it has a pKa in the range of 4-5.

  6. What HPLC column can I use for the analysis of Losartan in my samples?

    Losartan is commonly analyzed using a C18 RP-HPLC column.  Here at Supelco, we have successfully separated Valsartan, Losartan, and Irbesartan by HPLC chromatography on an Ascentis Express C18 15cm x 3mm column , using a mobile phase of 45:55, water:(0.1% formic acid in acetonitrile).  Run times were less than 3 minutes, with the flow rate set at 0.4 mL/min (35° C).

  7. What do you suggest for sample preparation?

    For extraction from biological fluids, consider HybridSPE - precipitation

  8. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

Michael D Kim et al.
ERJ open research, 7(1) (2021-02-04)
The aim was to determine whether losartan reduces cigarette smoke (CS)-induced airway inflammation and mucus hypersecretion in an in vitro model and a small clinical trial. Primary human bronchial epithelial cells (HBECs) were differentiated at the air-liquid interface (ALI) and
Simultaneous determination of losartan and hydrochlorothiazide in tablets by high-performance liquid chromatography
Carlucci G, et al.
Journal of Pharmaceutical and Biomedical Analysis, 23(1), 185-189 (2000)
LC/MS/MS method for the simultaneous estimation of losartan potassium and irbesartan in rat plasma
Prasad BGSVS, et al.
International Journal of Pharmacy and Pharmaceutical Sciences, 1(The), 206-215 (2009)
Mechanical stress-evoked but angiotensin II-independent activation of angiotensin II type 1 receptor induces cardiac hypertrophy through calcineurin pathway
Zhou N, et al
Biochemical and Biophysical Research Communications, 397, 263-269 (2010)
Christopher J Haddock et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 318(6), R1027-R1035 (2020-04-16)
There are examples of physiological conditions under which thirst is inappropriately exaggerated, and the mechanisms for these paradoxical ingestive behaviors remain unknown. We are interested in thirst mechanisms across the female life cycle and have identified a novel mechanism through
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