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Merck

81271

Polymyxin B solution

1 mg/mL in H2O, analytical standard

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A propos de cet article

Numéro CAS:
1405-20-5
UNSPSC Code:
41116107
NACRES:
NA.24
MDL number:
MFCD00131991

Principaux documents

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Nom du produit

Polymyxin B solution, 1 mg/mL in H2O, analytical standard

SMILES string

[S](=O)(=O)(O)O.N1CCC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C1=O)CCO)CCN)CCN)CC(C)C)Cc2ccccc2)CCN)NC(=O)C(NC(=O)C(NC(=O)C(NC=O)CCN)CCO)CCN

InChI

1S/C48H82N16O13.H2O4S/c1-27(2)24-37-47(76)59-32(11-19-52)41(70)56-31(10-18-51)43(72)61-35(14-22-65)39(68)54-21-13-34(45(74)57-33(12-20-53)44(73)64-38(48(77)63-37)25-28-6-4-3-5-7-28)60-42(71)30(9-17-50)58-46(75)36(15-23-66)62-40(69)29(8-16-49)55-26-67;1-5(2,3)4/h3-7,26-27,29-38,65-66H,8-25,49-53H2,1-2H3,(H,54,68)(H,55,67)(H,56,70)(H,57,74)(H,58,75)(H,59,76)(H,60,71)(H,61,72)(H,62,69)(H,63,77)(H,64,73);(H2,1,2,3,4)

InChI key

HNDFYNOVSOOGDU-UHFFFAOYSA-N

grade

analytical standard

concentration

1 mg/mL in H2O

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

antibiotic activity spectrum

Gram-negative bacteria
Gram-positive bacteria
fungi

application(s)

pharmaceutical (small molecule)

format

single component solution

mode of action

cell membrane | interferes

storage temp.

2-8°C

Quality Level

100

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Catégories apparentées

Application

Polymyxin B sulfate is a strongly cationic cyclic polypeptide antibiotic that is derived from fermentation of Bacilus polymyxa. It is a mixture of B1 and B2 sulfate. The product has been used clinically to treat infections of the urinary tract, meninges and blood stream caused by susceptible strains of Pseudomonas aeruginosa. It also has uses studying multidrug-resistant pathogens, as an immobilized agent for removal of endotoxins, and to induce pore formation in the membranes of cortex cells from excised sorghum roots.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

Mode of Action: Polymyxin B Sulfate binds to the lipid A portion of bacterial lipopolysaccharides, disrupting the cytoplasmic membrane by inducing pores large enough to permit nucleotide leakage in bacterial walls. This disrupts the permeability of the cytoplasmic membrane.

Mode of Resistance: The activity of Polymyxin B sulfate is inhibited by iron(II), Co(II), Mn(II) and Magnesium ions. Polymyxin B may also be incompaitible with other microbial agents, including amphoterecin, cephalothin sodium, cephasolin sodium and heparin sodium.

Antimicrobial Spectrum: Has bactericidal action on most gram-negative bacilli, including E. Coli and on most fungi and gram-positive bacteria.

General description

Chemical structure: peptide
Polymyxin B solution can find therapeutic applications as an antimicrobial agent, since it shows activity against multidrug-resistant (MDR) gram-negative bacterial infections.

Preparation Note

This product is concentrated at 1 mg/mL in water, and should be stored at 2-8°C.

Classe de stockage

12 - Non Combustible Liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves

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Certificats d'analyse (COA)

Lot/Batch Number
BCCM8325
BCCG2613
BCBZ4783
BCBR9102V

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Pharmacodynamics of polymyxin B against Pseudomonas aeruginosa
Tam.HV, et al.
Antimicrobial Agents and Chemotherapy, 49, 3624-3630 (2005)
Bernard Knoops et al.
Cell chemical biology, 25(5), 550-559 (2018-03-20)
Inflammation is a pathophysiological response of innate immunity to infection or tissue damage. This response is among others triggered by factors released by damaged or dying cells, termed damage-associated molecular pattern (DAMP) molecules that act as danger signals. DAMPs interact
Hazel Lin et al.
Small (Weinheim an der Bergstrasse, Germany), 16(35), e2002194-e2002194 (2020-08-04)
Graphene and other 2D materials, such as molybdenum disulfide, have been increasingly used in electronics, composites, and biomedicine. In particular, MoS2 and graphene hybrids have attracted a great interest for applications in the biomedical research, therefore stimulating a pertinent investigation
Manuel Roland Schmidli et al.
Frontiers in veterinary science, 7, 547644-547644 (2020-12-12)
Background: Canine intervertebral disc disease (IVDD) represents a significant clinical problem in veterinary medicine, with similarities to the human pathology. Host-derived damage-associated molecular patterns like fibronectin fragments (FnF) that develop during tissue dysfunction may be of specific relevance to IVD
Lee Sun New et al.
Analytical and bioanalytical chemistry, 405(4), 1407-1415 (2012-11-28)
With increasing multidrug resistance coupled to a poor development pipeline, clinicians are exploring antimicrobial combinations to improve treatment outcomes. In vitro hollow-fiber infection model (HFIM) is employed to simulate human in vivo drug clearance and investigate pharmacodynamic synergism of antibiotics.
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