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C0750

Caféine

powder, ReagentPlus®

Synonyme(s) :

1,3,7-triméthylxanthine

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A propos de cet article

Formule empirique (notation de Hill) :
C8H10N4O2
Numéro CAS:
58-08-2
Poids moléculaire :
194.19
UNSPSC Code:
12352210
NACRES:
NA.21
PubChem Substance ID:
24277682
EC Number:
200-362-1
Beilstein/REAXYS Number:
17705
MDL number:
MFCD00005758
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Quality Level

200

product line

ReagentPlus®

form

powder

mp

234-236.5 °C (lit.)

solubility

H2O: 15 mg/mL

SMILES string

CN1C(=O)N(C)c2ncn(C)c2C1=O

InChI

1S/C8H10N4O2/c1-10-4-9-6-5(10)7(13)12(3)8(14)11(6)2/h4H,1-3H3

InChI key

RYYVLZVUVIJVGH-UHFFFAOYSA-N

Gene Information

human ... ADORA1(134), ADORA2A(135), ADORA2B(136), ADORA3(140), PDE4B(5142), PRKAR1A(5573), PRKAR1AP(5574), PRKAR1B(5575), PRKAR2A(5576), PRKAR2B(5577)
mouse ... Adora2b(11541)
rat ... Adora1(29290), Adora2a(25369)

General description

Caffeine is a widely ingested pharmacologically active substance and is known to affect the central nervous system. It belongs to the class of methylxanthines. It is a naturally occurring alkaloid found in coffee, cocoa and other plants. Caffeine might be associated with osteoporosis, cardiovascular risk, arrhythmia and gastrointestinal disturbances. Caffeine is used to treat orthostatic hypotension, bronchopulmonary dysplasia and apnea of prematurity (AOP).

Application

Caffeine has been used:
  • to study its impact on the fluorescence of Petunia nuclei
  • as a stimulant to induce c-fos expression in rodents
  • as a component of defined media for the development of bovine oocytes in vitro

Biochem/physiol Actions

Caffeine is a natural stimulant that is most commonly found in coffee, tea and various other drinks. It is known for its effect on the central nervous system. It is also associated with insomnia, increased heart rate, digestive issues, creating anxiety and jitteriness. Caffeine is also associated with withdrawal symptoms like headaches, fatigue, irritability.

Features and Benefits

High purity product that can be used readily for HPLC applications along with other research applications.

Legal Information

ReagentPlus is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Keep tightly sealed.

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pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Classe de stockage

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Certificats d'analyse (COA)

Lot/Batch Number
0000527411
0000527425
0000527411
0000527425
0000521754

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Consulter la Bibliothèque de documents

Effects of caffeine and chlorogenic acid on propidium iodide accessibility to DNA: consequences on genome size evaluation in coffee tree
Noirot M, et al.
Annals of Botany, 92(2), 259-264 (2003)
A simple method for immunohistochemical staining of zebrafish brain sections for c-fos protein expression
Chatterjee D, et al.
Zebrafish, 12(6), 414-420 (2015)
L Keskintepe et al.
Biology of reproduction, 55(2), 333-339 (1996-08-01)
The objective was to establish an in vitro system in which bovine oocytes can be matured, fertilized, and cultured up to the blastocyst stage without support of serum, BSA, or somatic cells. Media consisted of modified tissue culture medium 199
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