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Merck

O0200000

Ouabain

European Pharmacopoeia (EP) Reference Standard

Synonyme(s) :

Ouabain octahydrate, 1β,3β,5β,11α,14,19-Hexahydroxycard-20(22)-enolide 3-(6-deoxy-α-L-mannopyranoside), Acocantherine, G-Strophanthin

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A propos de cet article

Formule empirique (notation de Hill) :
C29H44O12 · 8H2O
Numéro CAS:
11018-89-6
Poids moléculaire :
728.77
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329818827
MDL number:
MFCD00149240
Beilstein/REAXYS Number:
101712

Principaux documents

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Nom du produit

Ouabain, European Pharmacopoeia (EP) Reference Standard

InChI key

TYBARJRCFHUHSN-DMJRSANLSA-N

SMILES string

O.O.O.O.O.O.O.O.C[C@@H]1O[C@@H](O[C@H]2C[C@@H](O)[C@]3(CO)[C@H]4[C@H](O)C[C@]5(C)[C@H](CC[C@]5(O)[C@@H]4CC[C@]3(O)C2)C6=CC(=O)OC6)[C@H](O)[C@H](O)[C@H]1O

InChI

1S/C29H44O12.8H2O/c1-13-22(34)23(35)24(36)25(40-13)41-15-8-19(32)28(12-30)21-17(3-5-27(28,37)9-15)29(38)6-4-16(14-7-20(33)39-11-14)26(29,2)10-18(21)31;;;;;;;;/h7,13,15-19,21-25,30-32,34-38H,3-6,8-12H2,1-2H3;8*1H2/t13-,15-,16+,17+,18+,19+,21+,22-,23+,24+,25-,26+,27-,28+,29-;;;;;;;;/m0......../s1

grade

pharmaceutical primary standard

API family

ouabain

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

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Catégories apparentées

Application

Ouabain EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Other Notes

Sales restrictions may apply.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

Hazard Classifications

Acute Tox. 1 Oral - Acute Tox. 3 Inhalation - STOT RE 2

Classe de stockage

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

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Certificats d'analyse (COA)

Lot/Batch Number

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Andrée-Anne Marcoux et al.
The Journal of physiology, 597(16), 4263-4276 (2019-06-20)
Na+ -K+ -Cl- cotransporter type 2 (NKCC2) is a 27-exon membrane protein that is expressed in the thick ascending limb (TAL) of Henle where it is involved in reabsorption of the ultrafiltered NaCl load. It comes as three splice variants
Qin Gong et al.
Nature communications, 9(1), 4993-4993 (2018-11-28)
Signals arising from bacterial infections are detected by pathogen recognition receptors (PRRs) and are transduced by specialized adapter proteins in mammalian cells. The Receptor-interacting-serine/threonine-protein kinase 2 (RIPK2 or RIP2) is such an adapter protein that is critical for signal propagation
Stephen A Adefegha et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 83, 559-568 (2016-10-25)
This study assessed the possible protective mechanisms of protocatechuic acid (PCA) against cadmium (Cd)-induced oxidative stress and neurotoxicity in rats. Male wistar strain rats weighing between 150-160g were purchased and acclimatized for two weeks. The rats were divided into seven
Sarunporn Tandhavanant et al.
mBio, 9(4) (2018-07-26)
Many Gram-negative bacterial symbionts and pathogens employ a type III secretion system (T3SS) to live in contact with eukaryotic cells. Because T3SSs inject bacterial proteins (effectors) directly into host cells, the switching of secretory substrates between translocators and effectors in
V Hreniukh et al.
Cell biochemistry and function, 34(8), 579-587 (2016-11-20)
The goal of the study was to estimate the effect of a selective V-type H+ -ATPase inhibitor bafilomycin A1 and nicotinic acid adenine dinucleotide phosphate (NAADP) on energetic processes in NK/Ly cell by directly measuring the respiration of isolated mitochondria
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