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Merck

P4338

Poly(éthylène glycol)

greener alternative

average MN 3,350, hydroxyl, BioXtra

Synonyme(s) :

PEG

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A propos de cet article

Formule linéaire :
H(OCH2CH2)nOH
Numéro CAS:
25322-68-3
UNSPSC Code:
12352104
PubChem Substance ID:
24898527
NACRES:
NA.23
MDL number:
MFCD00081839

Principaux documents

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Nom du produit

Poly(éthylène glycol), BioXtra, average mol wt 3,350, powder

SMILES string

C(CO)O

InChI

1S/C2H6O2/c3-1-2-4/h3-4H,1-2H2

InChI key

LYCAIKOWRPUZTN-UHFFFAOYSA-N

product line

BioXtra

form

powder

mol wt

average mol wt 3,350

Quality Level

200

greener alternative product characteristics

Safer Solvents and Auxiliaries
Learn more about the Principles of Green Chemistry.

sustainability

Greener Alternative Product

impurities

≤0.01% Phosphorus (P)
≤0.1% Insoluble matter

solubility

water: soluble (PEG is soluble in water approximately 670 mg/ml, 20 °C)

density

1.0962 g/mL at 60 °C
1.0764 g/mL at 80 °C

anion traces

chloride (Cl-): ≤0.05%
sulfate (SO42-): ≤0.05%

cation traces

Al: ≤0.0005%
Ca: ≤0.0005%
Cu: ≤0.0005%
Fe: ≤0.0005%
K: ≤0.005%
Mg: ≤0.0005%
NH4+: ≤0.05%
Na: ≤0.05%
Pb: ≤0.001%
Zn: ≤0.0005%

Ω-end

hydroxyl

α-end

hydroxyl

greener alternative category

Aligned

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Catégories apparentées

Application

Poly (ethylene glycol) (PEG) can be used to functionalize magnetic nanoparticles in combination with nonionic surfactant Tween 80. PEG functionalization improves the biocompatibility of magnetite nanoparticles. It also reduces the surface charge and maintains the magnetic characteristics of nanoparticles.

PEG can be used as an exterior coating for the pharmaceutical final dosage forms. This can avoid moisture from encountering active pharmaceutical ingredients. For example, Naproxen solid dispersions are coated with PEG by drop printing technique. The PEG layer protects the solid dispersions from moisture-accelerated crystallization and enhances their stability.

Nanostructured hydroxyapatite (HAP) can be prepared by a sol-gel technique using PEG as an organic modifier. The addition of PEG has an influence on the morphology of HAP particles. At high temperatures, more flexible PEG molecules result in the formation of large-sized HAP platelets. At low synthesis temperatures, less flexible PEG colloids form nanostructured HAP.

PEG powder can also be used as a laxative agent.

General description

Polyethylene glycol (PEG) is a hydrophilic polymer. It can be easily synthesized by the anionic ring opening polymerization of ethylene oxide, into a range molecular weights and variety of end groups. When crosslinked into networks PEG can have high water content, forming “hydrogels”. PEG is a suitable material for biological applications because it does not trigger an immune response.
We are committed to bringing you Greener Alternative Products, which adhere to one or more of The 12 Principles of Green Chemistry. Polyethylene glycol (PEG) is an eco-friendly, biodegradable polymer widely used in pharmaceuticals and cosmetics. Its non-toxic nature and versatility make it a sustainable choice, derived from renewable resources, contributing to greener product formulations. Click here for more information.

Classe de stockage

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificats d'analyse (COA)

Lot/Batch Number
0000530285
0000530285
0000518107
WXBF8091V
0000518107

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Consulter la Bibliothèque de documents

Dafne Campigli Di Giammartino et al.
Nature cell biology, 21(10), 1179-1190 (2019-09-25)
Cell fate transitions are accompanied by global transcriptional, epigenetic and topological changes driven by transcription factors, as is exemplified by reprogramming somatic cells to pluripotent stem cells through the expression of OCT4, KLF4, SOX2 and cMYC. How transcription factors orchestrate
M A Thomson et al.
Archives of disease in childhood, 92(11), 996-1000 (2007-07-13)
To assess the efficacy and safety of polyethylene glycol 3350 plus electrolytes (PEG+E) for the treatment of chronic constipation in children. Randomised, double blind, placebo controlled crossover trial, with two 2-week treatment periods separated by a 2-week placebo washout. Six
Maria Paz Zafra et al.
Nature biotechnology, 36(9), 888-893 (2018-07-04)
CRISPR base editing enables the creation of targeted single-base conversions without generating double-stranded breaks. However, the efficiency of current base editors is very low in many cell types. We reengineered the sequences of BE3, BE4Gam, and xBE3 by codon optimization
Jacky Chow et al.
mSphere, 4(2) (2019-03-08)
Many fungal species, including pathogens, undergo a morphogenetic response called filamentous growth, where cells differentiate into a specialized cell type to promote nutrient foraging and surface colonization. Despite the fact that filamentous growth is required for virulence in some plant
Bárbara M Calisto et al.
Cell chemical biology, 28(1), 26-33 (2020-10-24)
Despite possessing only 32 residues, the tsetse thrombin inhibitor (TTI) is among the most potent anticoagulants described, with sub-picomolar inhibitory activity against thrombin. Unexpectedly, TTI isolated from the fly is 2000-fold more active and 180 Da heavier than synthetic and recombinant
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