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Merck

PHR1233

Biotine

Pharmaceutical Secondary Standard; Certified Reference Material

Synonyme(s) :

D-Biotine, Bios II, Coenzyme R, Vitamine B7, Vitamine H

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A propos de cet article

Formule empirique (notation de Hill) :
C10H16N2O3S
Numéro CAS:
58-85-5
Poids moléculaire :
244.31
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329823238
EC Number:
200-399-3
Beilstein/REAXYS Number:
86838
MDL number:
MFCD00005541

Principaux documents

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InChI

1S/C10H16N2O3S/c13-8(14)4-2-1-3-7-9-6(5-16-7)11-10(15)12-9/h6-7,9H,1-5H2,(H,13,14)(H2,11,12,15)/t6-,7-,9-/m0/s1

InChI key

YBJHBAHKTGYVGT-ZKWXMUAHSA-N

SMILES string

[H][C@]12CS[C@@H](CCCCC(O)=O)[C@@]1([H])NC(=O)N2

grade

certified reference material, pharmaceutical secondary standard

agency

traceable to Ph. Eur. B1116000, traceable to USP 1071508

API family

biotin

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

mp

231-233 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

Quality Level

300

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Catégories apparentées

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Biotin is a water-soluble vitamin, essential for amino acids and carbohydrates metabolism. It is involved in de novo synthesis of purine nucleotides and plays a role in gene expression and DNA replication.

Application

Biotin may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical preparations using a bio-sensing system and chromatography techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the US and EP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAC0265 in the slot below. This is an example certificate only and may not be the lot that you receive.

Classe de stockage

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificats d'analyse (COA)

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Using of HPLC coupled with coulometric detector for the determination of biotin in pharmaceuticals.
Zerzanova A, et al.
Journal of Pharmaceutical and Biomedical Analysis, 45(5), 730-735 (2007)
Determination of biotin in foodstuffs and pharmaceutical preparations using a biosensing system based on the streptavidin--biotin interaction.
Reyes FD, et al.
Analytica Chimica Acta, 436(1), 109-117 (2001)
Liquid chromatographic determination of biotin in multivitamin-multimineral tablets.
Ekpe AE and Hazen C
Journal of Pharmaceutical and Biomedical Analysis, 16(8), 1311-1315 (1998)
Yuxi Feng et al.
PloS one, 6(2), e16865-e16865 (2011-03-08)
Vasoregression is a hallmark of vascular eye diseases but the mechanisms involved are still largely unknown. We have recently characterized a rat ciliopathy model which develops primary photoreceptor degeneration and secondary vasoregression. To improve the understanding of secondary vasoregression in
Sung Jae Shin et al.
Clinical and vaccine immunology : CVI, 15(8), 1277-1281 (2008-06-14)
We previously reported that protein antigens of serodiagnostic potential were more abundant in culture filtrates than cellular extracts from liquid cultures of Mycobacterium avium subsp. paratuberculosis (D. Cho and M. T. Collins, Clin. Vaccine Immunol. 13:1155-1161, 2006). Based on this
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