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Merck

PHR1789

Doxorubicine hydrochloride

Pharmaceutical Secondary Standard; Certified Reference Material

Synonyme(s) :

DOX, Hydroxydaunorubicine hydrochloride

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A propos de cet article

Formule empirique (notation de Hill) :
C27H29NO11 · HCl
Numéro CAS:
25316-40-9
Poids moléculaire :
579.98
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329823614
EC Number:
246-818-3
Beilstein/REAXYS Number:
4229251
MDL number:
MFCD00077757

Principaux documents

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Nom du produit

Doxorubicine hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material

InChI key

MWWSFMDVAYGXBV-RUELKSSGSA-N

InChI

1S/C27H29NO11.ClH/c1-10-22(31)13(28)6-17(38-10)39-15-8-27(36,16(30)9-29)7-12-19(15)26(35)21-20(24(12)33)23(32)11-4-3-5-14(37-2)18(11)25(21)34;/h3-5,10,13,15,17,22,29,31,33,35-36H,6-9,28H2,1-2H3;1H/t10-,13-,15-,17-,22+,27-;/m0./s1

SMILES string

Cl[H].COc1cccc2C(=O)c3c(O)c4C[C@](O)(C[C@H](O[C@H]5C[C@H](N)[C@H](O)[C@H](C)O5)c4c(O)c3C(=O)c12)C(=O)CO

grade

certified reference material
pharmaceutical secondary standard

agency

USP 1225703
traceable to Ph. Eur. D2975000

API family

doxorubicin

form

powder

CofA

current certificate can be downloaded

packaging

pkg of 200 mg

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

216 °C (dec.) (lit.)

application(s)

pharmaceutical (small molecule)

storage temp.

-10 to -25°C

Quality Level

300

Gene Information

human ... TOP2A(7153)

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Catégories apparentées

Analysis Note

These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.

Application

This pharmaceutical secondary standard can also be used as follows:
  • Development of a reversed-phase high-performance liquid chromatographic (RP-HPLC) method combined with UV detection to determine doxorubicin hydrochloride in plasma samples
  • Electrochemical determination of doxorubicin by spinel-structured cobalt ferrite (CoFe2O4) modified carbon paste electrode in biological fluid and injection samples
  • Determination of doxorubicin hydrochloride in human plasma samples using a graphene quantum dots (GQDs) based electrochemical sensor
  • RP-HPLC method-based quantitative analysis of doxorubicin hydrochloride in vacuum foam dried formulations
  • Voltammetric determination of doxorubicin hydrochloride and dastinib using zinc oxide (ZnO) nanoparticle/1-butyl-3-methylimidazolium tetra-fluoroborate modified carbon paste electrode (ZnO-NPs/BMTFB/CPE) in their combined injection samples

General description

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Doxorubicin Hydrochloride is an anthracycline antibiotic, known for its broad range anti-cancer activities.

Other Notes

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
To see an example of a Certificate of Analysis for this material enter LRAB3692 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Carc. 1B - Muta. 1B - Repr. 1B

Classe de stockage

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

A simple HPLC bioanalytical method for the determination of doxorubicin hydrochloride in rat plasma: application to pharmacokinetic studies
Dharmalingam SR, et al.
Tropical Journal of Pharmaceutical Research, 13, 409-415 (2014)
Fast and sensitive determination of doxorubicin using multi-walled carbon nanotubes as a sensor and CoFe2O4 magnetic nanoparticles as a mediator
Taei M, et al.
Microchimica Acta, 183, 49-56 (2016)
Simultaneous determination of doxorubicin and dasatinib as two breast anticancer drugs uses an amplified sensor with ionic liquid and ZnO nanoparticle
Alavi-Tabari SAR, et al.
Journal of Electroanalytical Chemistry, 811, 84-88 (2018)
Development and validation of RP-HPLC method for determination of doxorubicin hydrochloride from vacuum foam dried formulation
Hajare AA, et al.
Research Journal of Pharmacy and Technology, 9, 1352-1356 (2016)
Yi-Fang Yang et al.
The Kaohsiung journal of medical sciences, 35(7), 408-416 (2019-04-20)
Breast cancer is the most common female-specific malignancy in Taiwan and developed countries worldwide, and its incidence continues to grow. 14-3-3ε (YWHAE), which belong to 14-3-3 family, it has been reported up-regulated in breast cancer tissues. However, the clinical implication
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