A5222

D-Amino Acid Oxidase from porcine kidney

Name: <SC>D</SC>-Amino Acid Oxidase from porcine kidney
Brand: SIGMA

powder, ≥1.5 units/mg solid

Synonyme(s) :

D-AAO, D-Amino acid: oxygen oxidoreductase (deaminating)

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About This Item

Numéro CAS:

9000-88-8

UNSPSC Code:

12352204

NACRES:

NA.54

EC Number:

232-563-5

MDL number:

MFCD00081546

Numéro CE :

1.4.3.3 (BRENDA, IUBMB)

Nom du produit

D-Amino Acid Oxidase from porcine kidney, powder, ≥1.5 units/mg solid

form

powder

specific activity

≥1.5 units/mg solid

storage temp.

−20°C

Quality Level

200

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Application

D-amino acid oxidase (DAO) is a potential target molecule for the treatment of chronic pain and schizophrenia . D-amino acid oxidase is used to oxidize D-amino acids to their corresponding imino acids.

Other Notes

One unit will oxidatively deaminate 1.0 μmole of D-alanine to pyruvate per minute at pH 8.3 at 25 °C, in the presence of a catalase.

Classe de stockage

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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d-Amino Acids and Classical Neurotransmitters in Healthy and Type 2 Diabetes-Affected Human Pancreatic Islets of Langerhans.

Cindy J Lee et al.

Metabolites, 12(9) (2022-09-24)

The pancreatic islets of Langerhans are clusters of cells that function as endocrine units synthesizing and releasing insulin and a range of additional peptide hormones. The structural and chemical characteristics of islets change during type 2 diabetes development. Although a

Glutamine 89 is a key residue in the allosteric modulation of human serine racemase activity by ATP.

Andrea V Canosa et al.

Scientific reports, 8(1), 9016-9016 (2018-06-15)

Serine racemase (SR) catalyses two reactions: the reversible racemisation of L-serine and the irreversible dehydration of L- and D-serine to pyruvate and ammonia. SRs are evolutionarily related to serine dehydratases (SDH) and degradative threonine deaminases (TdcB). Most SRs and TdcBs

Oligolamellar vesicles for covalent immobilization and stabilization of D-amino acid oxidase.

Makoto Yoshimoto et al.

Enzyme and microbial technology, 52(1), 13-19 (2012-12-04)

Oligolamellar phospholipid vesicles incorporated with d-amino acid oxidase from porcine kidney (OV-DAO) were prepared by encapsulating pre-formed enzyme-bound unilamellar vesicles (UV-DAO) with bilayers of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC). The bilayer of UV-DAO was composed of POPC, 30 mol% of cholesterol and 15

Pharmacodynamic effects of a D-amino acid oxidase inhibitor indicate a spinal site of action in rat models of neuropathic pain.

Seth C Hopkins et al.

The Journal of pharmacology and experimental therapeutics, 345(3), 502-511 (2013-03-23)

Inhibition of d-amino acid oxidase (DAAO) activity is a potential target for the treatment of chronic pain. Here we characterized the effects of systemic administration of the DAAO inhibitor 4H-furo[3,2-b]pyrrole-5-carboxylic acid (SUN) in rat models of neuropathic and inflammatory pain.

The degradation (by distinct pathways) of human D-amino acid oxidase and its interacting partner pLG72--two key proteins in D-serine catabolism in the brain.

Pamela Cappelletti et al.

The FEBS journal, 281(3), 708-723 (2013-11-19)

Human D-amino acid oxidase (EC 1.4.3.3; hDAAO) is a peroxisomal flavoenzyme significantly enriched in the mammalian brain. hDAAO has been proposed to play (with serine racemase; EC 5.1.1.18) an essential role in the catabolism of D-serine, an 'atypical' key signalling

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