A6060
Calpain Inhibitor II
powder
Synonyme(s) :
N-Acetyl-L-leucyl-L-leucyl-L-methioninal
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A propos de cet article
Formule empirique (notation de Hill) :
C19H35N3O4S
Numéro CAS:
Poids moléculaire :
401.56
UNSPSC Code:
12352200
NACRES:
NA.77
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
7693643
eCl@ss:
32110502
Service technique
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≥95% (HPLC)
Quality Level
form
powder
color
white
solubility
ethanol: 20 mg/mL
storage temp.
−20°C
SMILES string
[H]C(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O
InChI
1S/C19H35N3O4S/c1-12(2)9-16(20-14(5)24)19(26)22-17(10-13(3)4)18(25)21-15(11-23)7-8-27-6/h11-13,15-17H,7-10H2,1-6H3,(H,20,24)(H,21,25)(H,22,26)/t15-,16-,17-/m0/s1
InChI key
RJWLAIMXRBDUMH-ULQDDVLXSA-N
Application
Calpain inhibitor II is a cell-permeable peptide that restricts the activity of calpain, cathepsin L and cathepsin B. Calpain inhibitor II also prevents the methylmercury-induced cell death of cultured rat cerebellar neurons.
Calpain Inhibitor II has been used in western blotting. It has also been used to study the mechanism of Spy1A (a cyclin-like protein) degradation during cell cycle.
Biochem/physiol Actions
Calpain is a cysteine protease expressed in the nervous system. Calpain exhibits a calcium-dependent enzyme activity. In mice models, inhibition of calpain prevents leukocyte infiltration induced by angiotensin II and also attenuates prevascular inflammation.
Other Notes
Formerly CAS# 136632-32-1
Classe de stockage
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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J Sebastián Yakisich et al.
Investigational new drugs, 28(3), 242-250 (2009-03-17)
By using mini-units of tissue and protease inhibitors in short term incubation (0-180 min), we studied the role of proteolysis for ongoing DNA replication in the developing rat cerebral cortex. The protease inhibitors TLCK, TPCK, PMSF, MG-132 and PSI markedly
Motoharu Sakaue et al.
Toxicology, 213(1-2), 97-106 (2005-06-29)
Methylmercury, an environmental neurotoxicant, induces the apoptotic death of cerebellar granule cells in vitro at a low concentration. To further understand the mechanism of cell death, we used a rat cerebellar granule cell culture system to investigate whether the calpain/cyclin-dependent
Zachary A Gurard-Levin et al.
Antiviral research, 182, 104924-104924 (2020-09-09)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of the COVID-19 pandemic that began in 2019. The coronavirus 3-chymotrypsin-like cysteine protease (3CLpro) controls replication and is therefore considered a major target for antiviral discovery. This study describes the