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Merck

A8231

AGK2

≥97% (HPLC), powder

Synonyme(s) :

2-Cyano-3-[5-(2,5-dichlorophenyl)-2-furanyl]-N-5-quinolinyl-2-propenamide

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A propos de cet article

Formule empirique (notation de Hill) :
C23H13Cl2N3O2
Numéro CAS:
304896-28-4
Poids moléculaire :
434.27
NACRES:
NA.77
PubChem Substance ID:
329770953
UNSPSC Code:
12352200
MDL number:
MFCD01909444
Assay:
≥97% (HPLC)
Form:
powder
Quality level:
100

Principaux documents

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Nom du produit

AGK2, ≥97% (HPLC), powder

InChI key

SVENPFFEMUOOGK-SDNWHVSQSA-N

SMILES string

Clc1ccc(Cl)c(c1)-c2ccc(\C=C(/C#N)C(=O)Nc3cccc4ncccc34)o2

InChI

1S/C23H13Cl2N3O2/c24-15-6-8-19(25)18(12-15)22-9-7-16(30-22)11-14(13-26)23(29)28-21-5-1-4-20-17(21)3-2-10-27-20/h1-12H,(H,28,29)/b14-11+

assay

≥97% (HPLC)

form

powder

solubility

DMSO: 2 mg/mL, clear (warmed)
H2O: insoluble

storage temp.

room temp

Quality Level

100

Catégories apparentées

Application

AGK2 is a SIRT2 inhibitor. AGK2 has been used in a study to determine that SIRT2 inhibition induces cell death and decreases the intracellular ATP level. AGK2 also rescues dopamine neurons from α-synuclein toxicity in Parkinson′s disease models.

Biochem/physiol Actions

AGK2 is a SIRT2 inhibitor. AGK2 rescues dopamine neurons from α-synuclein toxicity in Parkinson′s disease models. IC50 for SIRT2 = 3.5 uM. AGK2 is >15-fold more selective for SIRT2 than SIRT1 and SIRT3. AGK2 may be the most selective SIRT2 inhibitor available.
AGK2 is a SIRT2 inhibitor; rescues dopamine neurons from α-synuclein toxicity in Parkinson′s disease models.

Features and Benefits

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Classe de stockage

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificats d'analyse (COA)

Lot/Batch Number
0000164387
0000164388
0000164387
0000164388
0000133363

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Consulter la Bibliothèque de documents

Hai-Bo Yu et al.
International journal of medical sciences, 15(12), 1356-1364 (2018-10-03)
Sirtuin 2 (SIRT2) is a nicotinamide adenine dinucleotide (NAD +)-dependent class III histone deacetylase. We have reported that HBx (hepatitis B virus X protein)-elevated SIRT2 promotes HBV replication and hepatocarcinogenesis. However, the potential anti-HBV effect of AGK2, a selective inhibitor
Lisa M Giammona et al.
Experimental hematology, 37(11), 1340-1352 (2009-09-01)
Megakaryocytic cells (Mks) undergo endomitosis and become polyploid. Mk ploidy correlates with platelet production. We previously showed that nicotinamide (NIC) greatly increases Mk ploidy in cultures of human mobilized peripheral blood CD34(+) cells. This study aims to examine the generality
David T She et al.
Molecular neurobiology, 55(12), 9188-9203 (2018-04-15)
Sirtuin 2 (SIRT2) is a family member of nicotinamide adenine dinucleotide (NAD+)-dependent deacetylases which appears to have detrimental roles in an array of neurological disorders such as Parkinson's disease (PD) and Huntington's disease (HD). In light of the recently emerging
G L Garrote et al.
The Journal of dairy research, 68(4), 639-652 (2002-04-04)
Chemical and microbiological composition of four Argentinean kefir grains from different sources as well as characteristics of the corresponding fermented milk were studied. Kefir grains CIDCA AGK1, AGK2 and AGK4 did not show significant differences in their chemical and microbiological
Sapna Singh et al.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 36(8), 6159-6171 (2015-03-22)
Sirtuins belong to the family of class III histone deacetylases; its role in neoplasia is controversial as both tumor-suppressive and promoting functions have been reported. There are very few reports available, where expressions of sirtuin isoforms are comprehensively analyzed during
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