B2517
6-Biopterin
≥97%
Synonyme(s) :
(1’R,2’S)-Biopterin, 2-Amino-4-hydroxy-6-(1,2-dihydroxypropyl)pteridine, L-erythro-6-(1,2-Dihydroxypropyl)pterin
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A propos de cet article
Formule empirique (notation de Hill) :
C9H11N5O3
Numéro CAS:
Poids moléculaire :
237.22
UNSPSC Code:
41106305
NACRES:
NA.51
PubChem Substance ID:
EC Number:
244-807-8
Beilstein/REAXYS Number:
87860
MDL number:
Form:
powder
Assay:
≥97%
Solubility:
1 M NaOH: soluble-10 mg/mL, clear, colorless to light greenish-yellow
Biological source:
synthetic
Service technique
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synthetic
Quality Level
assay
≥97%
form
powder
solubility
1 M NaOH: soluble-10 mg/mL, clear, colorless to light greenish-yellow
storage temp.
2-8°C
SMILES string
C[C@H](O)[C@H](O)c1cnc2NC(N)=NC(=O)c2n1
InChI
1S/C9H11N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h2-3,6,15-16H,1H3,(H3,10,11,13,14,17)/t3-,6-/m0/s1
InChI key
LHQIJBMDNUYRAM-DZSWIPIPSA-N
Application
6-Biopterin is an oxidation product from the melanogenesis regulating cofactor (6R)5,6,7,8 tetrahydrobiopterin (6-BH4). In vitro, 6-Biopterin is cytotoxic to melanocytes. However, in vivo, 6-Biopterin is rapidly and sequentially reduced back to 6-GH4 via q-BH2. Recent studies suggest that 6-Biopterin among other pteridines may be a useful non-invasive biomarker for cancer.
Classe de stockage
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Siew Ling Choy et al.
Scientific reports, 7(1), 9472-9472 (2017-08-27)
Intracellular pathogens belonging to the genus Leishmania have developed effective strategies that enable them to survive within host immune cells. Immunostimulatory compounds that counteract such immunological escape mechanisms represent promising treatment options for diseases. Here, we demonstrate that a lipopeptidephosphoglycan
Sanjeewa Gamagedara et al.
Clinica chimica acta; international journal of clinical chemistry, 412(1-2), 120-128 (2010-09-28)
Biomarkers are good potential tools for early cancer diagnosis. Here we have analyzed eight different pteridines in the urine samples of cancer patients and compared them with samples from healthy subjects. Pteridines are important cofactors in the process of cell
Abulizi Abudukadier et al.
Diabetes, 62(9), 3033-3043 (2013-05-08)
Endothelial nitric oxide synthase (eNOS) dysfunction induces insulin resistance and glucose intolerance. Tetrahydrobiopterin (BH4) is an essential cofactor of eNOS that regulates eNOS activity. In the diabetic state, BH4 is oxidized to 7,8-dihydrobiopterin, which leads to eNOS dysfunction owing to