C102

8-Cyclopentyl-1,3-dimethylxanthine

Name: 8-Cyclopentyl-1,3-dimethylxanthine
Brand: SIGMA

≥98% (HPLC), powder

Synonyme(s) :

8-Cyclopentyltheophylline, CPT

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Toutes les photos(1)

About This Item

Formule empirique (notation de Hill) :

C₁₂H₁₆N₄O₂

Numéro CAS:

35873-49-5

Poids moléculaire :

248.28

NACRES:

NA.77

PubChem Substance ID:

24277730

UNSPSC Code:

12352200

MDL number:

MFCD00055116

Nom du produit

8-Cyclopentyl-1,3-dimethylxanthine, ≥98% (HPLC), powder

InChI

1S/C12H16N4O2/c1-15-10-8(11(17)16(2)12(15)18)13-9(14-10)7-5-3-4-6-7/h7H,3-6H2,1-2H3,(H,13,14)

SMILES string

CN1C(=O)N(C)c2nc([nH]c2C1=O)C3CCCC3

InChI key

SCVHFRLUNIOSGI-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

powder

color

white to off-white

solubility

H₂O: slightly soluble <0.28 mg/mL
45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.77 mg/mL
DMSO: ~16 mg/mL at 60 °C
0.1 M NaOH: soluble

Quality Level

100

Gene Information

human ... ADORA1(134)

Biochem/physiol Actions

Selective A₁ adenosine receptor antagonist.

Features and Benefits

This compound is featured on the Adenosine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Classe de stockage

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificats d'analyse (COA)

Lot/Batch Number

0000474799

0000469282

0000258426

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Oscillatory neural networks underlying resting-state, attentional control and social cognition task conditions in children with ASD, ADHD and ASD+ADHD.

Elizabeth Shephard et al.

Cortex; a journal devoted to the study of the nervous system and behavior, 117, 96-110 (2019-04-08)

Autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD) are common and impairing neurodevelopmental disorders that frequently co-occur. The neurobiological mechanisms involved in ASD and ADHD are not fully understood. However, alterations in large-scale neural networks have been proposed as core

Homology directed repair is unaffected by the absence of siRNAs in Drosophila melanogaster.

Ines Schmidts et al.

Nucleic acids research, 44(17), 8261-8271 (2016-06-30)

Small interfering RNAs (siRNAs) defend the organism against harmful transcripts from exogenous (e.g. viral) or endogenous (e.g. transposons) sources. Recent publications describe the production of siRNAs induced by DNA double-strand breaks (DSB) in Neurospora crassa, Arabidopsis thaliana, Drosophila melanogaster and

Commensal microflora-induced T cell responses mediate progressive neurodegeneration in glaucoma.

Huihui Chen et al.

Nature communications, 9(1), 3209-3209 (2018-08-12)

Glaucoma is the most prevalent neurodegenerative disease and a leading cause of blindness worldwide. The mechanisms causing glaucomatous neurodegeneration are not fully understood. Here we show, using mice deficient in T and/or B cells and adoptive cell transfer, that transient

Kinetics of poly(ADP-ribosyl)ation, but not PARP1 itself, determines the cell fate in response to DNA damage in vitro and in vivo.

Harald Schuhwerk et al.

Nucleic acids research, 45(19), 11174-11192 (2017-10-05)

One of the fastest cellular responses to genotoxic stress is the formation of poly(ADP-ribose) polymers (PAR) by poly(ADP-ribose)polymerase 1 (PARP1, or ARTD1). PARP1 and its enzymatic product PAR regulate diverse biological processes, such as DNA repair, chromatin remodeling, transcription and

Wingless ligand 5a is a critical regulator of placental growth and survival.

Gudrun Meinhardt et al.

Scientific reports, 6, 28127-28127 (2016-06-18)

The maternal uterine environment is likely critical for human placental morphogenesis and development of its different trophoblast subtypes. However, factors controlling growth and differentiation of these cells during early gestation remain poorly elucidated. Herein, we provide evidence that the ligand

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