C127

CNQX

Name: CNQX
Brand: SIGMA

≥98% (HPLC), AMPA/kainate glutamate receptor antagonist, solid

Synonyme(s) :

6-Cyano-7-nitroquinoxaline-2,3-dione, FG-9065

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About This Item

Formule empirique (notation de Hill) :

C₉H₄N₄O₄

Numéro CAS:

115066-14-3

Poids moléculaire :

232.15

UNSPSC Code:

12352200

PubChem Substance ID:

24892392

NACRES:

NA.77

MDL number:

MFCD00069232

Nom du produit

CNQX, ≥98% (HPLC), solid

SMILES string

[O-][N+](=O)c1cc2NC(=O)C(=O)Nc2cc1C#N

InChI

1S/C9H4N4O4/c10-3-4-1-5-6(2-7(4)13(16)17)12-9(15)8(14)11-5/h1-2H,(H,11,14)(H,12,15)

InChI key

RPXVIAFEQBNEAX-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

solid

storage condition

protect from light

color

yellow

solubility

DMSO: >10 mg/mL
H₂O: insoluble

Biochem/physiol Actions

Potent, competitive AMPA/kainate glutamate receptor antagonist.

Other Notes

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

Application

CNQX has been used:

as an α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)/kainate blocker to study its effects on cytoneme formation in pluripotent embryonic stem cells (pESCs)
glutamate blocker to reduce the synaptic input during current-clamp recordings in central antennal lobe neurons
as a non-N-methyl-D-aspartate (NMDA) receptor blocker to study its effects on the heart rate in rats

Classe de stockage

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

VGLUT2 Trafficking Is Differentially Regulated by Adaptor Proteins AP-1 and AP-3.

Haiyan Li et al.

Frontiers in cellular neuroscience, 11, 324-324 (2017-11-11)

Release of the major excitatory neurotransmitter glutamate by synaptic vesicle exocytosis depends on glutamate loading into synaptic vesicles by vesicular glutamate transporters (VGLUTs). The two principal isoforms, VGLUT1 and 2, exhibit a complementary pattern of expression in adult brain that

Chronic intermittent hypoxia impairs heart rate responses to AMPA and NMDA and induces loss of glutamate receptor neurons in nucleus ambiguous of F344 rats.

Binbin Yan et al.

American journal of physiology. Regulatory, integrative and comparative physiology, 296(2), R299-R308 (2008-11-21)

Chronic intermittent hypoxia (CIH), as occurs in sleep apnea, impairs baroreflex-mediated reductions in heart rate (HR) and enhances HR responses to electrical stimulation of vagal efferent. We tested the hypotheses that HR responses to activation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) and

Oligodendroglial excitability mediated by glutamatergic inputs and Nav1.2 activation.

Emmanuelle Berret et al.

Nature communications, 8(1), 557-557 (2017-09-17)

Oligodendrocyte (OL) maturation and axon-glial communication are required for proper myelination in the developing brain. However, physiological properties of OLs remain largely uncharacterized in different brain regions. The roles of oligodendroglial voltage-activated Na+ channels (Nav) and electrical excitability in relation

Pyramidal neurons derived from human pluripotent stem cells integrate efficiently into mouse brain circuits in vivo.

Ira Espuny-Camacho et al.

Neuron, 77(3), 440-456 (2013-02-12)

The study of human cortical development has major implications for brain evolution and diseases but has remained elusive due to paucity of experimental models. Here we found that human embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs), cultured

The paracetamol metabolite N-acetylp-benzoquinone imine reduces excitability in first- and second-order neurons of the pain pathway through actions on KV7 channels.

Sutirtha Ray et al.

Pain, 160(4), 954-964 (2019-01-03)

Paracetamol (acetaminophen, APAP) is one of the most frequently used analgesic agents worldwide. It is generally preferred over nonsteroidal anti-inflammatory drugs because it does not cause typical adverse effects resulting from the inhibition of cyclooxygenases, such as gastric ulcers. Nevertheless

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