C239

CNQX disodium salt hydrate

Name: CNQX disodium salt hydrate
Brand: SIGMA

≥98% (HPLC), solid, AMPA/kainate receptor antagonist.

Synonyme(s) :

6-Cyano-7-nitroquinoxaline-2,3-dione disodium salt hydrate

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About This Item

Formule empirique (notation de Hill) :

C₉H₂N₄Na₂O₄ · xH₂O

Numéro CAS:

115066-14-3

Poids moléculaire :

276.12 (anhydrous basis)

UNSPSC Code:

12352200

PubChem Substance ID:

24277972

NACRES:

NA.77

MDL number:

MFCD09953908

Nom du produit

CNQX disodium salt hydrate, ≥98% (HPLC), solid

SMILES string

O.[Na+].[Na+].[O-]c1nc2cc(C#N)c(cc2nc1[O-])[N+]([O-])=O

InChI

1S/C9H4N4O4.2Na.H2O/c10-3-4-1-5-6(2-7(4)13(16)17)12-9(15)8(14)11-5;;;/h1-2H,(H,11,14)(H,12,15);;;1H2/q;2*+1;/p-2

InChI key

LCDWHGXMFAZHEO-UHFFFAOYSA-L

assay

≥98% (HPLC)

form

solid

storage condition

protect from light

color

orange to red

solubility

H₂O: >2 mg/mL (warmed)

Application

CNQX disodium salt hydrate has been used as:

as a competitive non-NMDA receptor antagonist and competitive AMPA/kainate receptor antagonist in neuronal cultures(110)
as a glutamatergic blockers for measuring inhibitory postsynaptic currents in projection neurons(111)
as a AMPA glutamate receptor antagonist prefrontal cortex neurons(112)

Biochem/physiol Actions

CNQX(6-cyano-7-nitroquinoxaline-2,3-dioneis) is a potent, competitive AMPA/kainate receptor antagonist. It is a quinoxaline derivative and also an antagonist for non-N-methyl-d-aspartate (non-NMDA) glutamate receptor. CNQX mediates depolarization thalamic reticular nucleus via α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors (AMPARs). It displays micromolar affinity towards AMPA/kainate receptor.

Potent, competitive AMPA/kainate receptor antagonist.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Classe de stockage

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

CNQX Blocks Kainate-induced Corneal Irritation

Ibitokun, Bernadette O and Miller, Kenneth E

investigate opthalmology and visual science, 53(14), 1855-1855 (2012)

Medicinal chemistry of competitive kainate receptor antagonists

Larsen, Ann M and Bunch, Lennart

ACS Chemical Neuroscience, 2(2), 60-74 (2010)

Binge-like consumption of a palatable food accelerates habitual control of behavior and is dependent on activation of the dorsolateral striatum.

Teri M Furlong et al.

The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(14), 5012-5022 (2014-04-04)

Access to highly palatable and calorically dense foods contributes to increasing rates of obesity worldwide. Some have made the controversial argument that consumption of such foods can lead to "food addiction," yet little is known about how long-term access to

Selective excitatory actions of DNQX and CNQX in rat thalamic neurons

Lee SH, et al.

Journal of Neurophysiology, 103(4), 1728-1734 (2010)

Calmodulin kinase IV-dependent CREB activation is required for neuroprotection via NMDA receptor-PSD95 disruption.

Karen F S Bell et al.

Journal of neurochemistry, 126(2), 274-287 (2013-02-01)

NMDA-type glutamate receptors mediate both trophic and excitotoxic signalling in CNS neurons. We have previously shown that blocking NMDAR- post-synaptic density-95 (PSD95) interactions provides significant protection from excitotoxicity and in vivo ischaemia; however, the mechanism of neuroprotection is unclear. Here

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