C9911
(S)-(+)-camptothécine
≥90% (HPLC), powder, DNA topoisomerase I inhibitor
Synonyme(s) :
(S)-4-Ethyl-4-hydroxy-1H-pyrano-[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
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About This Item
Nom du produit
(S)-(+)-camptothécine, ≥90% (HPLC), powder
InChI
1S/C20H16N2O4/c1-2-20(25)14-8-16-17-12(7-11-5-3-4-6-15(11)21-17)9-22(16)18(23)13(14)10-26-19(20)24/h3-8,25H,2,9-10H2,1H3/t20-/m0/s1
SMILES string
CC[C@@]1(O)C(=O)OCC2=C1C=C3N(Cc4cc5ccccc5nc34)C2=O
InChI key
VSJKWCGYPAHWDS-FQEVSTJZSA-N
assay
≥90% (HPLC)
form
powder
mp
260 °C (dec.) (lit.)
solubility
chloroform/methanol (4:1): 5 mg/mL
antibiotic activity spectrum
neoplastics
mode of action
DNA synthesis | interferes
enzyme | inhibits
storage temp.
2-8°C
Quality Level
Gene Information
human ... TOP1(7150)
mouse ... Prkca(18750)
rat ... Sstr2(54305)
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Catégories apparentées
Biochem/physiol Actions
Features and Benefits
Other Notes
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral - Muta. 1B
Classe de stockage
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
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Which document(s) contains shelf-life or expiration date information for a given product?
If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.
How do I get lot-specific information or a Certificate of Analysis?
The lot specific COA document can be found by entering the lot number above under the "Documents" section.
What is Product C9911, (S)-(+)-Camptothecin, soluble in?
This product is soluble in DMSO (10 mg/mL). At higher concentrations, heating is required for the product to dissolve completely (approximately 10 minutes at 95°C), but some precipitation occurs upon cooling to room temperature. It is also soluble in 1 N NaOH (50 mg/mL).
What is the solution stability of Product C9911, (S)-(+)-Camptothecin?
Stock solutions of camptothecin in DMSO can be stored at -20°C for up to 3 months.
What is the extinction coefficient of Product C9911, (S)-(+)-Camptothecin?
The millimolar extinction coefficients (EmM) at various wavelengths are 37.3 (220 nm); 29.2 (254 nm); 4.9 (290 nm); 19.9 (370 nm).
How do I find price and availability?
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Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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