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Merck

D3072

Doxycycline Hydrochloride, Ready Made Solution

100 mg/mL in DMSO, ≥95.0% (HPLC)

Synonyme(s) :

α-6-Deoxy-5-hydroxytetracycline hydrochloride, 2-Naphthacenecarboxamide, 4-(dimethylamino)- 1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, hydrochloride (1:1), (4S,4aR,5S,5aR,6R,12aS)-, Doxylin, Idocyklin, Vibramycin hyclate, Vibramycin hydrochloride

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A propos de cet article

Formule empirique (notation de Hill) :
C22H24N2O8 · HCl
Numéro CAS:
10592-13-9
Poids moléculaire :
480.90
NACRES:
NA.85
UNSPSC Code:
51284028
MDL number:
MFCD03427564

Principaux documents

Voir toute la documentation
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InChI

1S/C22H24N2O8.ClH/c1-7-8-5-4-6-9(25)11(8)16(26)12-10(7)17(27)14-15(24(2)3)18(28)13(21(23)31)20(30)22(14,32)19(12)29;/h4-7,10,14-15,17,25-27,31-32H,23H2,1-3H3;1H/b21-13-;/t7-,10+,14+,15-,17-,22-;/m0./s1

InChI key

VLUQVUWDECWBTL-UQVCFKGQSA-N

biological source

synthetic

sterility

0.22 μm filtered

assay

≥95.0% (HPLC)

form

liquid

concentration

100 mg/mL in DMSO

solubility

DMSO: 100 mg/mL

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria, mycoplasma, parasites

mode of action

protein synthesis | interferes

storage temp.

−20°C

Quality Level

200

Catégories apparentées

General description

Doxycycline is a member of the tetracycline antibiotics group, and is commonly used to treat a variety of infections. It is a Broad spectrum antibiotic and bacteriostatic. Doxycycline shows antiprotozoal properties and is a potent inhibitor of MMPs (matrix metalloproteinases) in vivo.

Application

<ul>
<li><strong>AAPS PharmSciTech: </strong>Creation of a PVA/PCL/CS-based nanofibrous membrane incorporating doxycycline hydrochloride for guided tissue regeneration and controlled delivery in the management of periodontitis, evaluated in vivo in rats (Mirzaeei et al., 2024).</li>
<li><strong>European Journal of Pharmacology: </strong>Doxycycline hydrochloride′s role in inhibiting the progression of malignant rhabdoid tumor of the kidney by targeting MMP17 and MMP1 through the PI3K-Akt signaling pathway (Mi et al., 2024).</li>
</ul>

Other Notes

Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.

Classe de stockage

10 - Combustible liquids

wgk

WGK 3

flash_point_f

188.6 °F - closed cup

flash_point_c

87 °C - closed cup

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Certificats d'analyse (COA)

Lot/Batch Number
0000419621
0000419621
0000408895
0000408895
0000366924

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Consulter la Bibliothèque de documents

Megan E Forrest et al.
PloS one, 15(2), e0228730-e0228730 (2020-02-14)
Messenger RNA (mRNA) degradation plays a critical role in regulating transcript levels in the cell and is a major control point for modulating gene expression. In yeast and other model organisms, codon identity is a powerful determinant of transcript stability
Youcai Tang et al.
PloS one, 13(8), e0200897-e0200897 (2018-08-02)
Alpha-1 Antitrypsin (α1AT) Deficiency is a genetic disease in which accumulation of α1AT mutant Z (α1ATZ) protein in the ER of hepatocytes causes chronic liver injury, liver fibrosis, and hepatocellular carcinoma. No effective medical therapy is currently available for the
Adam W Whisnant et al.
Nature communications, 11(1), 2038-2038 (2020-04-29)
The predicted 80 open reading frames (ORFs) of herpes simplex virus 1 (HSV-1) have been intensively studied for decades. Here, we unravel the complete viral transcriptome and translatome during lytic infection with base-pair resolution by computational integration of multi-omics data.
Benedetta Assetta et al.
Journal of visualized experiments : JoVE, (165) (2020-11-24)
In Alzheimer's disease (AD) and other neurodegenerative disorders, oligodendroglial failure is a common early pathological feature, but how it contributes to disease development and progression, particularly in the gray matter of the brain, remains largely unknown. The dysfunction of oligodendrocyte
Yannick Bongrand et al.
The Canadian veterinary journal = La revue veterinaire canadienne, 53(10), 1109-1113 (2013-04-02)
An atypical case of Mycoplasma pneumonia with an unusual radiographic and computed tomographic pattern was diagnosed in a Siamese kitten. The cat showed no response to broad-spectrum antibiotic therapy including enrofloxacin. The administration of doxycycline led to a dramatic clinical
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