D3314
D-erythro-Dihydrosphingosine
≥98%
Synonyme(s) :
Sphinganine
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A propos de cet article
Formule empirique (notation de Hill) :
C18H39NO2
Numéro CAS:
Poids moléculaire :
301.51
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352211
MDL number:
Service technique
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Laissez-nous vous aiderbiological source
synthetic (organic)
Quality Level
assay
≥98%
form
solid
color
white
solubility
DMSO: 25 mg/mL (warm), ethanol: 25 mg/mL (warm)
lipid type
sphingolipids
storage temp.
−20°C
SMILES string
OC[C@@](N)([H])[C@]([H])(O)CCCCCCCCCCCCCCC
InChI
1S/C18H39NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h17-18,20-21H,2-16,19H2,1H3/t17-,18+/m0/s1
InChI key
OTKJDMGTUTTYMP-ZWKOTPCHSA-N
Application
D-erythro-Dihydrosphingosine has been used:
- as a standard lipid in quantification assay
- in kinetics assay
- to determine serine palmitoyl transferase activity
Biochem/physiol Actions
Biosynthetic precursor to sphingosine; inhibits protein kinase C.
D-erythro-Dihydrosphingosine is a natural stereoisomer. The levels of dihydrosphingosine (DHS) is increased during unfolded protein response (UPR).
Classe de stockage
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Contenu apparenté
The UPR Activator ATF6 Responds to Proteotoxic and Lipotoxic Stress by Distinct Mechanisms
Tam AB, et al.
Developmental Cell, 46(3), 327-343 (2018)
Birgitte Lindegaard et al.
PloS one, 13(1), e0186755-e0186755 (2018-01-18)
Interleukin (IL)-18 is involved in regulation of lipid and glucose metabolism. Mice lacking whole-body IL-18 signalling are prone to develop weight gain and insulin resistance, a phenotype which is associated with impaired fat oxidation and ectopic skeletal muscle lipid deposition.
The Lipid Status in Patients with Ulcerative Colitis: Sphingolipids are Disease-Dependent Regulated.
Sarah Bazarganipour et al.
Journal of clinical medicine, 8(7) (2019-07-07)
The factors that contribute to the development of ulcerative colitis (UC), are still not fully identified. Disruption of the colon barrier is one of the first events leading to invasion of bacteria and activation of the immune system. The colon