D4434
Dichloromethylenediphosphonic acid disodium salt
osteoclastic activity inhibitor, powder
Synonyme(s) :
Cl2MDP, Clodronate disodium, Clodronic acid disodium salt, DMDP
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A propos de cet article
Formule linéaire :
CH2O6Cl2Na2P2
Numéro CAS:
Poids moléculaire :
288.86
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352106
EC Number:
245-078-9
MDL number:
Form:
powder
Quality level:
Service technique
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Dichloromethylenediphosphonic acid disodium salt,
form
powder
Quality Level
solubility
water: 49.00-51.00 mg/mL, clear, colorless
storage temp.
room temp
SMILES string
[Na+].[Na+].OP([O-])(=O)C(Cl)(Cl)P(O)([O-])=O
InChI
1S/CH4Cl2O6P2.2Na/c2-1(3,10(4,5)6)11(7,8)9;;/h(H2,4,5,6)(H2,7,8,9);;/q;2*+1/p-2
InChI key
HJKBJIYDJLVSAO-UHFFFAOYSA-L
Gene Information
rat ... Man2a1(25478), Si(497756)
Biochem/physiol Actions
Analog of pyrophosphate ion that inhibits the osteoclastic activity leading to bone resorption and osteoporosis. The compound is used in cancer research, especially in skeletal metastases and breast carcinoma. When entrapped in liposomes, it is used for macrophage-selective depletion (macrophage "suicide" technique), especially in spleen and liver. Found also to inhibit collagenase and matrix metalloproteinase1.
Classe de stockage
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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O Teronen et al.
Calcified tissue international, 61(1), 59-61 (1997-07-01)
Interstitial collagenase present in human jaw cyst extract and purified human fibroblast-type collagenase (MMP-1) were both efficiently inhibited in vitro by clodronate, an osteoactive, antiresorptive bisphosphonate. The IC50 of clodronate to inhibit MMP-1 is 150 microM. These findings suggest an
Michiko Itoh et al.
PloS one, 8(12), e82163-e82163 (2013-12-19)
Although macrophages are thought to be crucial for the pathogenesis of chronic inflammatory diseases, how they are involved in disease progression from simple steatosis to non-alcoholic steatohepatitis (NASH) is poorly understood. Here we report the unique histological structure termed "hepatic
Valérie Lebrun et al.
Clinical science (London, England : 1979), 125(11), 501-511 (2013-06-14)
Alcohol consumption is a major cause of liver disease. It also associates with increased cardiovascular risk and Type 2 diabetes. ALD (alcoholic liver disease) and NAFLD (non-alcoholic fatty liver disease) share pathological features, pathogenic mechanisms and pattern of disease progression.