E006
β-Carboline-3-carboxylic acid N-methylamide
Benzodiazepine receptor inverse agonist, solid
Synonyme(s) :
β-CCA methylamide, FG-7142, N-Methyl-β-carboline-3-carboxamide
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A propos de cet article
Formule empirique (notation de Hill) :
C13H11N3O
Numéro CAS:
Poids moléculaire :
225.25
UNSPSC Code:
12352106
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Form:
solid
Quality level:
Service technique
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Laissez-nous vous aiderNom du produit
β-Carboline-3-carboxylic acid N-methylamide,
form
solid
Quality Level
color
light tan
solubility
DMSO: >10 mg/mL, H2O: insoluble
SMILES string
CNC(=O)c1cc2c(cn1)[nH]c3ccccc23
InChI
1S/C13H11N3O/c1-14-13(17)11-6-9-8-4-2-3-5-10(8)16-12(9)7-15-11/h2-7,16H,1H3,(H,14,17)
InChI key
QMCOPDWHWYSJSA-UHFFFAOYSA-N
Gene Information
human ... BZRAP1(9256)
Biochem/physiol Actions
Benzodiazepine inverse receptor agonist; potent anxiogenic agent.
Features and Benefits
This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
Disclaimer
Solutions may be stored for several days at 4 °C.
Classe de stockage
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Natale R Sciolino et al.
Behavioural brain research, 233(1), 191-200 (2012-05-15)
Although exercise improves anxiety in humans, it is controversial whether exercise is anxiolytic in rodents. We tested the hypothesis that stress influences the effect of exercise on anxiety-like and defensive behaviors. To explore the neurobiological mechanisms of exercise, we also
Hongrun Yu et al.
PloS one, 7(8), e42684-e42684 (2012-08-29)
Post-traumatic stress disorder (PTSD) is an anxiety disorder that not only affects mental health, but may also affect bone health. However, there have been no studies to examine the direct relationship between PTSD and bone. We employed electric shocks in
Philip L Johnson et al.
Physiology & behavior, 107(5), 733-742 (2012-05-05)
Although the hypothalamic orexin system is known to regulate appetitive behaviors and promote wakefulness and arousal (Sakurai, 2007 [56]), this system may also be important in adaptive and pathological anxiety/stress responses (Suzuki et al., 2005 [4]). In a recent study