Accéder au contenu
Merck

E6627

cis-5,8,11,14,17-Eicosapentaenoic acid sodium salt

synthetic (organic), ≥99% (capillary GC), 5-Lipoxygenase inhibitor, film or powder

Se connecter pour consulter les tarifs organisationnels et contractuels.

Sélectionner une taille de conditionnement

Toutes les photos(1)

About This Item

Formule linéaire :
CH3(CH2CH=CH)5(CH2)3CO2Na
Numéro CAS:
73167-03-0
Poids moléculaire :
324.43
UNSPSC Code:
12352211
PubChem Substance ID:
24894631
NACRES:
NA.77
MDL number:
MFCD00079184

Nom du produit

cis-5,8,11,14,17-Eicosapentaenoic acid sodium salt, ≥99% (capillary GC)

SMILES string

[Na].CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O

InChI

1S/C20H30O2.Na.H/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22;;/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-19H2,1H3,(H,21,22);;/b4-3-,7-6-,10-9-,13-12-,16-15-;;

InChI key

TVEGTERCKGGVCJ-LIJGWLRISA-N

biological source

synthetic (organic)

assay

≥99% (capillary GC)

form

film or powder

color

white to off-white

solubility

methanol: 50 mg/mL, clear to slightly hazy, colorless to faintly yellow

shipped in

dry ice

storage temp.

−20°C

Quality Level

200

Gene Information

human ... ALOX5(240)
mouse ... ALOX5(11689)
rat ... ALOX5(25290)

Vous recherchez des produits similaires ? Visite Guide de comparaison des produits

Catégories apparentées

Application

cis-5,8,11,14,17-Eicosapentaenoic acid sodium salt has been used:
  • to study its effect on the pathology of lupus in drug-induced and spontaneous mouse models
  • to pretreat mouse alveolar macrophages to study the effect/relationship between amiodarone and eicosapentaenoic acid (EPA) concerning the cytokine release
  • to examine if pharmacological correction with EPA supplementation might restore autophagic flux and reduce renal lipotoxicity in mice

Biochem/physiol Actions

5-Lipoxygenase inhibitor; reduces thromboxane A2 production.
Eicosapentaenoic acid (EPA) possesses anti-hyperglycemic, anti-oxidant, anti-hyperlipidemic, and anti-inflammatory properties. It aids in improving vasoreactivity. EPA is capable of suppressing vascular smooth muscle proliferation. It ameliorates pulmonary hypertension by preventing Fyn kinase activity. EPA exhibits a beneficial effect on lipid metabolism. It is used to treat hypercholesterolemia and atherosclerosis.

General description

Eicosapentaenoic acid (EPA)/timnodonic acid is an omega-3 polyunsaturated fatty acid (PUFA). This long-chain fatty acid is mainly found in fish oil.

Classe de stockage

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Faites votre choix parmi les versions les plus récentes :

Certificats d'analyse (COA)

Lot/Batch Number
0000455364
0000455364
0000324839
0000310503
0000324839

Vous ne trouvez pas la bonne version ?

Si vous avez besoin d'une version particulière, vous pouvez rechercher un certificat spécifique par le numéro de lot.

Rechercher un(e) COA

Déjà en possession de ce produit ?

Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Y Futamura
Japanese journal of pharmacology, 69(4), 335-341 (1995-12-01)
I studied the effect of amiodarone, a cationic amphiphilic drug, on the cytokine release and protein kinase C (PKC) activity of mouse alveolar macrophages. In addition, I examined the relationship between amiodarone and eicosapentaenoic acid (EPA) with respect to the
Lin Hai Kurahara et al.
Journal of molecular and cellular cardiology, 148, 50-62 (2020-09-06)
Pulmonary arterial hypertension (PAH) is a multifactorial disease characterized by pulmonary arterial vasoconstriction and remodeling. Src family tyrosine kinases, including Fyn, play critical roles in vascular remodeling via the inhibition of STAT3 signaling. EPA is known to inhibit Fyn kinase
Azusa Kobayashi et al.
Frontiers in immunology, 12, 650856-650856 (2021-07-03)
Accumulating evidence suggests that cholesterol accumulation in leukocytes is causally associated with the development of autoimmune diseases. However, the mechanism by which fatty acid composition influences autoimmune responses remains unclear. To determine whether the fatty acid composition of diet modulates
Yong-Ping Zhang et al.
Prostaglandins, leukotrienes, and essential fatty acids, 136, 85-94 (2017-08-06)
Omega-3 polyunsaturated fatty acids (n-3 PUFAs), docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), have been reported to prevent neurodegenerative diseases such as Alzheimer's disease (AD) in both experimental and clinical/epidemiological studies. However, whether DHA and EPA from natural products exert
Takeshi Yamamoto et al.
Autophagy, 17(7), 1700-1713 (2020-06-18)
Recently, we identified a novel mechanism of lipotoxicity in the kidney proximal tubular cells (PTECs); lipid overload stimulates macroautophagy/autophagy for the renovation of plasma and organelle membranes to maintain the integrity of the PTECs. However, this autophagic activation places a

Notre équipe de scientifiques dispose d'une expérience dans tous les secteurs de la recherche, notamment en sciences de la vie, science des matériaux, synthèse chimique, chromatographie, analyse et dans de nombreux autres domaines..

Contacter notre Service technique