F8423
Fluorouracil
meets USP testing specifications
Synonyme(s) :
5-Fluorouracil, 2,4-Dihydroxy-5-fluoropyrimidine, 5-FU, 5-Fluoro-2,4(1H,3H)-pyrimidinedione
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A propos de cet article
Formule empirique (notation de Hill) :
C4H3FN2O2
Numéro CAS:
Poids moléculaire :
130.08
UNSPSC Code:
12352207
NACRES:
NA.71
PubChem Substance ID:
EC Number:
200-085-6
Beilstein/REAXYS Number:
127172
MDL number:
Quality level:
Service technique
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agency
USP/NF, meets USP testing specifications
mp
282-286 °C (dec.) (lit.)
application(s)
pharmaceutical (small molecule)
SMILES string
FC1=CNC(=O)NC1=O
InChI
1S/C4H3FN2O2/c5-2-1-6-4(9)7-3(2)8/h1H,(H2,6,7,8,9)
InChI key
GHASVSINZRGABV-UHFFFAOYSA-N
Gene Information
human ... TYMS(7298)
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral - Carc. 2
Classe de stockage
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
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Aurélien Montagu et al.
European journal of medicinal chemistry, 46(2), 778-786 (2011-01-15)
The synthesis and antiviral evaluation of a series of C5-(1,4- and 1,5-disubstituted-1,2,3-triazolo)-nucleoside derivatives is described. The key steps of this synthesis are regioselective Huisgen's 1,3-dipolar cycloaddition, using either copper-catalyzed azide-alkyne cycloaddition (CuAAC) or ruthenium-catalyzed azide-alkyne cycloaddition (RuAAC) under microwave activation.
Julia K J Ahlskog et al.
Bioorganic & medicinal chemistry letters, 19(16), 4851-4856 (2009-07-21)
We describe the synthesis and characterization of two acetazolamide derivatives containing either a charged fluorophore or an albumin-binding moiety, which restrict binding to carbonic anhydrase IX and XII present on tumor cells. In vivo studies showed the preferentially targeting of
Zhiyang Chen et al.
Nature communications, 6, 6808-6808 (2015-04-17)
Wild-type p53-induced phosphatase 1 (Wip1) negatively regulates several tumour suppressor and DNA damage response pathways. However, the impact of Wip1 on haematopoietic stem cell (HSC) homeostasis and aging remains unknown. Here we show that Wip1 is highly expressed in HSCs