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Adenosine 5′-triphosphate (ATP) disodium salt hydrate

≥90%, bacterial (Corynebacterium sp), lyophilized powder

Synonyme(s) :

ATP disodium hydrate

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A propos de cet article

Formule linéaire :
C10H14N5O13P3Na2 · xH2O
Numéro CAS:
34369-07-8
Poids moléculaire :
551.14 (anhydrous basis)
eCl@ss:
32160414
PubChem Substance ID:
24895005
NACRES:
NA.26
EC Number:
213-579-1
MDL number:
MFCD00150755
UNSPSC Code:
12352208
Assay:
≥90%
Biological source:
bacterial (Corynebacterium sp)
Form:
lyophilized powder
Solubility:
water: soluble, clear, colorless (1 vial + 0.1 mL)
Storage temp.:
−20°C
Service technique
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Nom du produit

Adenosine 5′-triphosphate (ATP) disodium salt hydrate, vial of ~1 mg ATP

biological source

bacterial (Corynebacterium sp)

Quality Level

200

assay

≥90%

form

lyophilized powder

packaging

vial of ~1 mg ATP

solubility

water: soluble, clear, colorless (1 vial + 0.1 mL)

storage temp.

−20°C

SMILES string

Nc1ncnc2n(cnc12)[C@@H]3O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]3O

InChI

1S/C10H16N5O13P3.2Na.H2O/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20;;;/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20);;;1H2/q;2*+1;/p-2/t4-,6-,7-,10-;;;/m1.../s1

InChI key

NTBQNWBHIXNPRU-MSQVLRTGSA-L

Application

Adenosine 5′-triphosphate (ATP) disodium salt hydrate has been:
  • used as a standard to measure ATP by bioluminescence method
  • used in kinase buffer to assess the interaction between death-associated protein kinases (DAPK2) and 14-3-3-β
  • used as a standard in ATP colorimetric assay

Biochem/physiol Actions

Adenosine 5′-triphosphate was shown to have inhibitory effects on the inflammatory response by abrogating secretion of TNF-α and promoting secretion of Interleukin-10.
P2 purinergic agonist; increases activity of Ca2+-activated K+ channels; substrate for ATP-dependent enzyme systems
Adenosine 5′-triphosphate (ATP) is one of the nucleoside triphosphate present in living system. It controls various biologic processes such as glucose metabolism, muscle contraction and neurotransmission. Apart from this, ATP serves as an important energy source for the cell. Administration of ATP might be useful in the treatment of non-small-cell lung cancer.

Preparation Note

Each vial contains ~1.2 mg of Na2ATP • 3H2O equivalent to ~1.0 mg of ATP (2.0 μmol). Actual amount printed on the label.
Prepared to be substantially vanadium-free.

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11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificats d'analyse (COA)

Lot/Batch Number
0000536363
0000536362
0000536363
0000536362
0000492797

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Contenu apparenté

Necrostatin-1 attenuates mitochondrial dysfunction in neurons and astrocytes following neonatal hypoxia--ischemia
Chavez-Valdez R, et al.
Neuroscience, 219, 192-203 (2012)
Els L R Swennen et al.
European journal of immunology, 35(3), 852-858 (2005-02-19)
In vitro studies suggest that extracellular nucleotides and nucleosides may be important regulators of inflammatory and immune responses. Most studies with adenosine 5'-triphosphate (ATP) have been performed in cell lines, which are remote from the human situation. The purpose of
Andrei A Ivanov et al.
Journal of medicinal chemistry, 50(6), 1166-1176 (2007-02-17)
A rhodopsin-based homology model of the nucleotide-activated human P2Y2 receptor, including loops, termini, and phospholipids, was optimized with the Monte Carlo multiple minimum conformational search routine. Docked uridine 5'-triphosphate (UTP) formed a nucleobase pi-pi complex with conserved Phe3.32. Selectivity-enhancing 2'-amino-2'-deoxy
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