G1796
Glycolide
≥99%
Synonyme(s) :
1,4-Dioxane-2,5-dione
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A propos de cet article
Formule empirique (notation de Hill) :
C4H4O4
Numéro CAS:
Poids moléculaire :
116.07
NACRES:
NA.23
PubChem Substance ID:
UNSPSC Code:
12162002
EC Number:
207-954-9
MDL number:
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Laissez-nous vous aiderInChI
1S/C4H4O4/c5-3-1-7-4(6)2-8-3/h1-2H2
InChI key
RKDVKSZUMVYZHH-UHFFFAOYSA-N
SMILES string
O=C1COC(=O)CO1
assay
≥99%
mp
82-86 °C (lit.)
shipped in
dry ice
storage temp.
−20°C
Quality Level
Catégories apparentées
General description
Glycolide is a cyclic dimer of α-hydroxy acid that can be used in the formation of aliphatic polyester. It is synthesized by the dimerization of glycolic acid. It forms a low toxic synthetic biodegradable polymer that can be used in medical applications. It is majorly used in the formation of a highly crystalline poly(glycolide) by ring opening polymerization.
Application
Glycolide can be used as a monomer in the preparation of poly(lactic-co-glycolide)(PGLA) via copolymerization with lactide monomer. PGLA is further used in the following applications:
- Porous PGLA microsphere scaffolds are used in bone repair applications.
- Encapsulated PGLA nanoparticles can be used in drug delivery and tissue engineering applications. Polymeric micro/nanoparticles made from PLGA have gained significant interest for their appealing characteristics, including biodegradability, biocompatibility, prolonged drug release, and safeguarding the drug against degradation.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2
Classe de stockage
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Biomedical applications of PLGA particles
Agrawal A, et al.
Materials for Biomedical Engineering, 87-129 (2019)
Towards electroactive gel artificial muscle structures
Electroactive Polymer Actuators and Devices (EAPAD) XX, 10594, 1059408-1059408 (2018)
Anne Marit de Groot et al.
Journal of controlled release : official journal of the Controlled Release Society, 266, 27-35 (2017-09-18)
The skin is an attractive organ for immunization due to the presence of a large number of epidermal and dermal antigen-presenting cells. Hollow microneedles allow for precise and non-invasive intradermal delivery of vaccines. In this study, ovalbumin (OVA)-loaded poly(lactic-co-glycolic acid)
Types of biodegradable polymers
Introduction of Bioplastic Engineering, 81-151 (2016)
Meital Ben David-Naim et al.
Biomaterials, 145, 154-167 (2017-09-02)
siRNA-loaded nanoparticles (NPs) administered systemically can overcome the poor stability and rapid elimination of free double-stranded RNA in circulation, resulting in increased tumor accumulation and efficacy. siRNA against osteopontin (siOPN), a protein involved in breast cancer development, was encapsulated in
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