G2140

L-Glutathione oxidized disodium salt

Name: <SC>L</SC>-Glutathione oxidized disodium salt
Brand: SIGMA

suitable for cell culture, BioReagent

Synonyme(s) :

GSSG

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About This Item

Formule empirique (notation de Hill) :

C₂₀H₃₀N₆Na₂O₁₂S₂

Numéro CAS:

103239-24-3

Poids moléculaire :

656.59

MDL number:

MFCD00148894

UNSPSC Code:

12352209

PubChem Substance ID:

24895087

NACRES:

NA.75

Beilstein/REAXYS Number:

6265389

Nom du produit

L-Glutathione oxidized disodium salt, suitable for cell culture, BioReagent

SMILES string

[Na+].[Na+].N[C@@H](CCC(=O)N[C@@H](CSSC[C@H](NC(=O)CC[C@H](N)C([O-])=O)C(=O)NCC(O)=O)C(=O)NCC([O-])=O)C(O)=O

InChI

1S/C20H32N6O12S2.2Na/c21-9(19(35)36)1-3-13(27)25-11(17(33)23-5-15(29)30)7-39-40-8-12(18(34)24-6-16(31)32)26-14(28)4-2-10(22)20(37)38;;/h9-12H,1-8,21-22H2,(H,23,33)(H,24,34)(H,25,27)(H,26,28)(H,29,30)(H,31,32)(H,35,36)(H,37,38);;/q;2*+1/p-2/t9-,10-,11-,12-;;/m0../s1

InChI key

DRFILBXQKYDTFW-JIWRMXRASA-L

biological source

yeast

product line

BioReagent

assay

≥98%

form

powder

technique(s)

cell culture | mammalian: suitable

impurities

ethanol, essentially free

solubility

water: 50 mg/mL, clear, colorless to very faintly yellow

storage temp.

−20°C

Quality Level

200

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Application

For use in cell culture applications as an antioxidant and heavy metal detoxification agent. L-Glutathione oxidized disodium salt has been used in semen processing and evaluation.

Biochem/physiol Actions

Oxidized L-glutathione is frequently measured in vivo as an indicator of oxidative stress.

Classe de stockage

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificats d'analyse (COA)

Lot/Batch Number

0000476135

0000393784

SLCQ4335

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Influence of various antioxidants on microscopic-oxidative stress indicators and fertilizing ability of frozen-thawed bull semen

Sariozkan S, et al.

Acta Veterinaria Brno, 78(3), 463-469 (2009)

Oxidized forms of glutathione in peripheral blood as biomarkers of oxidative stress.

Rossi R

Clinical Chemistry, 52(7), 1406-1414 (2006)

Comparative physiological, metabolomic, and transcriptomic analyses reveal mechanisms of improved abiotic stress resistance in bermudagrass [Cynodon dactylon (L). Pers.] by exogenous melatonin.

Haitao Shi et al.

Journal of experimental botany, 66(3), 681-694 (2014-09-17)

Melatonin (N-acetyl-5-methoxytryptamine), a well-known animal hormone, is also involved in plant development and abiotic stress responses. In this study, it is shown that exogenous application of melatonin conferred improved salt, drought, and cold stress resistances in bermudagrass. Moreover, exogenous melatonin

Interaction of MIF Family Proteins in Myocardial Ischemia/Reperfusion Damage and Their Influence on Clinical Outcome of Cardiac Surgery Patients.

Christian Stoppe et al.

Antioxidants & redox signaling, 23(11), 865-879 (2015-08-04)

Cardiac surgery involves myocardial ischemia/reperfusion (I/R) with potentially deleterious consequences. Macrophage migration inhibitory factor (MIF) is a stress-regulating chemokine-like cytokine that protects against I/R damage, but functional links with its homolog, d-dopachrome tautomerase (MIF-2), and the circulating soluble receptor CD74

Aldehydic load and aldehyde dehydrogenase 2 profile during the progression of post-myocardial infarction cardiomyopathy: benefits of Alda-1.

Katia M S Gomes et al.

International journal of cardiology, 179, 129-138 (2014-12-03)

We previously demonstrated that reducing cardiac aldehydic load by aldehyde dehydrogenase 2 (ALDH2), a mitochondrial enzyme responsible for metabolizing the major lipid peroxidation product, protects against acute ischemia/reperfusion injury and chronic heart failure. However, time-dependent changes in ALDH2 profile, aldehydic

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