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Merck

H1650

Monoclonal Anti-HLA Class I Antigen antibody produced in mouse

clone W6/32, purified immunoglobulin, buffered aqueous solution

Synonyme(s) :

Monoclonal Anti-HLA Class I Antigen

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A propos de cet article

NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
W6/32, monoclonal
Application:
flow cytometry
immunoprecipitation (IP)
indirect immunofluorescence
Species reactivity:
monkey, human
Citations:
43
Technique(s):
flow cytometry: 5 μL using 1 × 106 cells
immunoprecipitation (IP): suitable
indirect immunofluorescence: 1:10 using acetone-fixed human tonsil frozen sections.
Uniprot accession no.:
P04439

Principaux documents

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Nom du produit

Monoclonal Anti-HLA Class I Antigen antibody produced in mouse, clone W6/32, purified immunoglobulin, buffered aqueous solution

biological source

mouse

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

W6/32, monoclonal

form

buffered aqueous solution

species reactivity

monkey, human

technique(s)

flow cytometry: 5 μL using 1 × 106 cells
immunoprecipitation (IP): suitable
indirect immunofluorescence: 1:10 using acetone-fixed human tonsil frozen sections.

isotype

IgG2a

UniProt accession no.

P04439

shipped in

wet ice

storage temp.

2-8°C

target post-translational modification

unmodified

Quality Level

200

Gene Information

human ... HLA-A(3105), HLA-B(3106), HLA-C(3107)

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Catégories apparentées

Application

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunofluorescence (1 paper)

Biochem/physiol Actions

HLA class I molecules like HLA-A, -B and −C help in the presentation of endogenous antigen to CD8+ (cluster of differentiation 8) T cells.
Recognizes the human HLA Class I antigen expressed on most human nucleated cells. The antibody reacts with a monomorphic epitope on the 44-45 kDa α-chain polypeptide of human class I HLA molecules (HLA-A,B,C). The antibody may be used in immunoprecipitation, complement mediated cytotoxicity, flow cytometry and immunohistochemical staining of acetone-fixed, frozen sections and cell smears. It cross-reacts with cells from African and Asian apes and old world monkeys. No reactivity is seen with cells from most new world monkeys or from non-primates. The epitope recognized by this antibody is sensitive to routine formalin fixation and paraffin embedding.
4th Workshop: code no. P1
5th Workshop: code nos. BP166, BP288, BP407, B 005

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Class I proteins are highly polymorphic, in which HLA-B seems to be the most polymorphic gene in the human genome. HLA-A, -B, -C are classical class I proteins and are heterodimers. HLA-A, -B, -C consists of a polymorphic transmembrane α heavy chain and an invariant water-soluble light chain. HLA-B is located on human chromosome 6p21.

The previously assigned protein identifier P01891 has been merged into P04439. Full details can be found on the UniProt database.

Immunogen

human tonsil leukocyte membrane preparation.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 15 mM sodium azide

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Classe de stockage

12 - Non Combustible Liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificats d'analyse (COA)

Lot/Batch Number
0000508176
0000483650
0000483650
0000458245
0000458245

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Consulter la Bibliothèque de documents

Kian Kani et al.
Molecular cancer therapeutics, 11(5), 1071-1081 (2012-03-14)
Clinical oncology is hampered by lack of tools to accurately assess a patient's response to pathway-targeted therapies. Serum and tumor cell surface proteins whose abundance, or change in abundance in response to therapy, differentiates patients responding to a therapy from
Wenjing Du et al.
Oncogenesis, 7(4), 36-36 (2018-04-25)
The transcriptional factor SALL4, an important stem cell regulator, is expressed in hematopoietic stem cells and various malignancies, but its role in EGFR-mutated NSCLCs has not been studied yet. Here, we report that the expression of Sal-like protein 4 (SALL4)
Xi-Wen Jiang et al.
Molecular medicine reports, 20(1), 593-603 (2019-05-23)
Targeted drugs have been widely used in the treatment of patients with lung cancer, particularly for those with non‑small cell lung cancer (NSCLC). Plasma cell‑free DNA is an emerging clinical tool for the detection of epidermal growth factor receptor (EGFR)
The human gene map for performance and health-related fitness phenotypes: the 2005 update
Rankinen T, et al.
Med Sci Sports Exerc., 38(11), 1863-1888 (2006)
Major histocompatibility complex class II
The Systematic Identification of Organic Compounds, 3-19 (2011)
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