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H9377

Hypoxanthine

Name: Hypoxanthine
Brand: SIGMA

≥99.0%, synthetic (organic), powder

Synonyme(s) :

6-Hydroxypurine

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A propos de cet article

Formule empirique (notation de Hill) :

C₅H₄N₄O

Numéro CAS:

68-94-0

Poids moléculaire :

136.11

NACRES:

NA.51

PubChem Substance ID:

24895850

UNSPSC Code:

41106305

EC Number:

200-697-3

MDL number:

MFCD00005725

Beilstein/REAXYS Number:

5811

Assay:

≥99.0%

Biological source:

synthetic (organic)

Form:

powder

Service technique

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Propriétés

Nom du produit

Hypoxanthine, ≥99.0%

biological source

synthetic (organic)

Quality Level

200, 300

assay

≥99.0%

form

powder

SMILES string

O=C1NC=Nc2nc[nH]c12

InChI

1S/C5H4N4O/c10-5-3-4(7-1-6-3)8-2-9-5/h1-2H,(H2,6,7,8,9,10)

InChI key

FDGQSTZJBFJUBT-UHFFFAOYSA-N

Description

Application

Hypoxanthine is a nutrient additive for a variety of cell culture applications involving bacterial, parasite (Plasmodium falciparum) and animal cells. Hypoxanthine is a component of selection media used in hybridoma technologies.

Hypoxanthine has been used:

to gavage mice and to evaluate the activity of xanthine oxidase (XO) in pasteurized whole milk in vivo in potassium oxonate (PO) -induced mouse model of hyperuricemia
as a supplement in Iscove′s modified Dulbecco′s medium (IMDM) medium to cultivate in-vitro cell line (EL-1 cells)
as a pure standard for the quantification of hypoxanthine in vitreous fluid sample using high-performance liquid chromatography-ultra-violet (HPLC-UV) for the estimation of post-mortem interval

Biochem/physiol Actions

Hypoxanthine acts as an intermediate in purine metabolism. It elicits a vital role as a 5′-base of the anticodon in a few transfer-RNAs. Though similar to guanine (Gua), it is devoid of the exocyclic amino group at C(2) position. It may be used as a substrate to study the specificity and kinetics of hypoxanthine-guanine phosphoribosyl transferases.

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