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Merck

I0899

Imipramine hydrochloride

BioXtra, ≥99% (TLC)

Synonyme(s) :

10,11-Dihydro-N,N-dimethyl-5H-dibenz[b,f]azepine-5-propanamine hydrochloride, 5-[3-(Dimethylamino)propyl]-10,11-dihydro-5H-dibenz[b,f]azepine hydrochloride

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A propos de cet article

Formule empirique (notation de Hill) :
C19H24N2 · HCl
Numéro CAS:
113-52-0
Poids moléculaire :
316.87
NACRES:
NA.25
PubChem Substance ID:
24895912
UNSPSC Code:
12352116
EC Number:
204-030-7
MDL number:
MFCD00012669

Principaux documents

Voir toute la documentation
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InChI key

XZZXIYZZBJDEEP-UHFFFAOYSA-N

InChI

1S/C19H24N2.ClH/c1-20(2)14-7-15-21-18-10-5-3-8-16(18)12-13-17-9-4-6-11-19(17)21;/h3-6,8-11H,7,12-15H2,1-2H3;1H

SMILES string

Cl[H].CN(C)CCCN1c2ccccc2CCc3ccccc13

product line

BioXtra

assay

≥99% (TLC)

form

powder

impurities

≤0.0005% Phosphorus (P), ≤0.1% Insoluble matter

ign. residue

≤0.1%

solubility

H2O: 50 mg/mL, colorless to faintly yellow

anion traces

sulfate (SO42-): ≤0.05%

cation traces

Al: ≤0.0005%, Ca: ≤0.005%, Cu: ≤0.0005%, Fe: ≤0.005%, K: ≤0.005%, Mg: ≤0.0005%, NH4+: ≤0.05%, Na: ≤0.005%, Pb: ≤0.001%, Zn: ≤0.0005%

Quality Level

200

Gene Information

human ... SLC6A2(6530), SLC6A4(6532)

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Catégories apparentées

Application


  • Novel, fast, and reliable electrochemical dsDNA biosensor based on O-terminated pristine nanocrystalline boron-doped diamond electrode for DNA interaction studies.: Research featuring a novel electrochemical dsDNA biosensor that facilitates the study of DNA interactions with imipramine hydrochloride, enhancing our understanding of its genotoxic effects and providing crucial insights for biochemistry applications (Augustín M et al., 2024).

  • Comparison of two pharmacological protocols for inducing ex copula ejaculation in donkeys.: In this comparative study, imipramine hydrochloride is used within a pharmacological protocol, offering significant insights into veterinary applications and animal reproductive studies (Khan FA et al., 2024).

  • Development of Visible Spectrophotometric Methods for the Determination of Tricyclic Antidepressants Based on Formation of Molecular Complexes with p-Benzoquinones.: This publication outlines a novel spectrophotometric method for analyzing tricyclic antidepressants like imipramine hydrochloride, providing an efficient tool for quantitative analysis in pharmaceutical and clinical research (Ciuca MD et al., 2023).

Biochem/physiol Actions

Tricyclic antidepressant; inhibits the serotonin and norepinephrine transporters with Kis of 7.7 nM and 67 nM, respectively. Has little effect on the dopamine transporter (Ki = 25 μM).
Tricyclic antidepressant; inhibits the serotonin and norepinephrine transporters; has little effect on the dopamine transporter.

hcodes

H300

pictograms

Skull and crossbones
GHS06

signalword

Danger

Hazard Classifications

Acute Tox. 2 Oral

Classe de stockage

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificats d'analyse (COA)

Lot/Batch Number
0000503902
0000503902
0000422892
0000422892
0000317033

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Consulter la Bibliothèque de documents

Steven Chen et al.
Communications biology, 3(1), 747-747 (2020-12-23)
Approximately 10% of the world's population is at risk of schistosomiasis, a disease of poverty caused by the Schistosoma parasite. To facilitate drug discovery for this complex flatworm, we developed an automated high-content screen to quantify the multidimensional responses of
Adam J Walker et al.
Behavioural brain research, 242, 76-83 (2013-01-02)
Several animal models are currently utilised in the investigation of major depressive disorder; however, each is validated by its response to antidepressant pharmacotherapy. Few animal models consider the notion of antidepressant treatment resistance. Chronic daily administration of adrenocorticotropic hormone (ACTH)
Ana Laura de la Garza et al.
Nutrients, 11(3) (2019-03-15)
Maternal hypercaloric exposure during pregnancy and lactation is a risk factor for developing diseases associated with inflammation such as obesity, diabetes and, neurological diseases in the offspring. Neuroinflammation might modulate neuronal activation and flavonoids are dietary compounds that have been
Management of nocturnal enuresis.
Patrina H Y Caldwell et al.
BMJ (Clinical research ed.), 347, f6259-f6259 (2013-10-31)
Alexander Carpinteiro et al.
Cell reports. Medicine, 1(8), 100142-100142 (2020-11-10)
The acid sphingomyelinase/ceramide system plays an important role in bacterial and viral infections. Here, we report that either pharmacological inhibition of acid sphingomyelinase with amitriptyline, imipramine, fluoxetine, sertraline, escitalopram, or maprotiline or genetic downregulation of the enzyme prevents infection of
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