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Merck

L8912

L-Leucine

98.5-101.0%, suitable for cell culture, non-animal source, meets EP, JP, USP testing specifications

Synonyme(s) :

(S)-Leucine, (S)-2-Amino-4-methylpentanoic acid

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About This Item

Formule linéaire :
(CH3)2CHCH2CH(NH2)CO2H
Numéro CAS:
61-90-5
Poids moléculaire :
131.17
NACRES:
NA.26
PubChem Substance ID:
24896510
eCl@ss:
32160406
UNSPSC Code:
12352209
EC Number:
200-522-0
MDL number:
MFCD00002617
Beilstein/REAXYS Number:
1721722

Nom du produit

L-Leucine, from non-animal source, meets EP, JP, USP testing specifications, suitable for cell culture, 98.5-101.0%

assay

98.5-101.0%

form

powder

SMILES string

CC(C)C[C@H](N)C(O)=O

InChI

1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1

InChI key

ROHFNLRQFUQHCH-YFKPBYRVSA-N

biological source

non-animal source

agency

USP/NF
meets EP testing specifications
meets JP testing specifications
meets USP testing specifications

optical activity

[α]20/D 14.9 to 16.0°, c = 4 in 6 M HCl
[α]25/D 14.9 to 17.3 °, c = 4 in 6 M HCl

quality

meets EP, JP, USP testing specifications

technique(s)

cell culture | mammalian: suitable

impurities

endotoxin, tested

color

white

mp

>300 °C (lit.)

solubility

1 M HCl: 50 mg/mL

cation traces

As: ≤1 ppm
Fe: ≤10 ppm
NH4+: <0.02%
heavy metals: ≤10 ppm

application(s)

peptide synthesis
pharmaceutical (small molecule)

functional group

amine
carboxylic acid

storage temp.

room temp

Quality Level

300

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Catégories apparentées

Application

L-Leucine has been used:

  • as a hypertrophic agent to monitor its effects on myotubes.
  • as a component of PMG media for culturing yeast.
  • in myotube protein synthesis analysis in skeletal muscle cells.
  • to study its effects on hepatic lipid metabolism.

Biochem/physiol Actions

Leucine plays a role in intracellular signaling, gene transcription, and translation. It promotes the synthesis of protein by activating the mammalian target of the rapamycin (mTOR) signaling pathway in placental cells, skeletal muscles, and adipose tissue. Leucine inhibits protein degradation and promotes mitochondrial biogenesis, glucose metabolism, and fatty acid oxidation to provide energy for protein synthesis.

General description

Leucine is a non-glucogenic, and essential amino acid. It is a branched-chain amino acid that is a structural component of proteins.

Other Notes

For additional information on our range of Biochemicals, please complete this form.
The product is intended for laboratory use only, and it is not suitable for drug, household, or other purposes.

Classe de stockage

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificats d'analyse (COA)

Lot/Batch Number
0000515034
0000515033
0000515032
0000515033
0000515032

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

(-)-Epicatechin and its colonic metabolite hippuric acid protect against dexamethasone-induced atrophy in skeletal muscle cells
Edwards S J, et al.
The Journal of Nutritional Biochemistry, 110, 109150- 109150 (2022)
Optimization of an in vitro bioassay to monitor growth and formation of myotubes in real time
Sylvia M
Bioscience Reports (2016)
Leucine in Obesity: Therapeutic Prospects
Yao K, et al.
Trends in Pharmacological Sciences, 37(8), 714-727 (2016)
The role of leucine and its metabolites in protein and energy metabolism
Duan Y, et al.
Amino Acids, 48(1), 41-51 (2016)
Eric R. Braverman
The Healing Nutrients Within: Facts, Findings, and New Research on Amino Acids (2003)
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