L9908
LY-294,002 hydrochloride
from microbial (Staphylococcus roseus), ≥98% (HPLC), solid, PI3K inhibitor
Synonyme(s) :
2-(4-Morpholinyl)-8-phenyl-1(4H)-benzopyran-4-one hydrochloride
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A propos de cet article
Formule empirique (notation de Hill) :
C19H17NO3 · HCl
Numéro CAS:
Poids moléculaire :
343.80
UNSPSC Code:
12352207
PubChem Substance ID:
NACRES:
NA.77
MDL number:
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Laissez-nous vous aiderNom du produit
LY-294,002 hydrochloride, solid, ≥98% (HPLC)
biological source
microbial (Staphylococcus roseus)
Quality Level
assay
≥98% (HPLC)
form
solid
color
white to off-white
solubility
DMSO: >5 mg/mL, H2O: insoluble
storage temp.
2-8°C
SMILES string
O=C1C=C(Oc2c1cccc2-c3ccccc3)N4CCOCC4
InChI
1S/C19H17NO3/c21-17-13-18(20-9-11-22-12-10-20)23-19-15(7-4-8-16(17)19)14-5-2-1-3-6-14/h1-8,13H,9-12H2
InChI key
CZQHHVNHHHRRDU-UHFFFAOYSA-N
General description
LY-294,002 hydrochloride is a derivative of the flavonoid, quercetin and elicits higher inhibition on the enzyme phosphoinositide 3-kinase (PI3K). LY-294,002 inhibits nuclear factor kappa B signaling in macrophages. It elevates expression of autophagosomal protein LC3 and promotes apoptosis in gastric and nasopharyngeal cancer cells. LY-294,002 modulates action potential repolarization and improves myocyte contractility.
Application
LY-294,002 hydrochloride has been used in the inhibition of:
- phosphoinositide 3-kinase (PI3K) in human lung cancer cell line
- autophagy in mesenchymal stem cells (MSCs).
- serine/threonine-specific protein kinase (AKT) signaling in fibroblasts and cardiac cells.
Biochem/physiol Actions
Specific cell permeable phosphatidylinositol 3-kinase inhibitor.
Features and Benefits
This compound is a featured product for Cyclic Nucleotide and Kinase Phosphatase Biology research. Discover more featured Cyclic Nucleotide and Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the G Proteins (Heterotrimeric) and Phosphoinositide Kinases pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Classe de stockage
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Contenu apparenté
The Phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 modulates cytokine expression in macrophages via p50 nuclear factor kappa B inhibition, in a PI3K-independent mechanism
Avni D, et al.
Biochemical Pharmacology, 83(1), 106-114 (2012)
Phosphatidylinositol 3-kinase inhibitor (LY294002) induces apoptosis of human nasopharyngeal carcinoma in vitro and in vivo
Jiang H, et al.
Journal of Experimental & Clinical Cancer Research, 29(1), 34-34 (2010)
Class I phosphatidylinositol 3-kinase inhibitor LY294002 activates autophagy and induces apoptosis through p53 pathway in gastric cancer cell line SGC7901
Xing C, et al.
Acta biochimica et biophysica Sinica, 40(3), 194-201 (2008)