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Merck

M0199

Mdivi-1

≥98% (HPLC), powder, mitochondrial division DRP inhibitor

Synonyme(s) :

3-(2,4-Dichloro-5-methoxyphenyl)-2,3-dihydro-2-thioxo-4(1H)-quinazolinone, 3-(2,4-Dichloro-5-methoxyphenyl)-2-sulfanyl-4(3H)-quinazolinone

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About This Item

Formule empirique (notation de Hill) :
C15H10Cl2N2O2S
Numéro CAS:
338967-87-6
Poids moléculaire :
353.22
UNSPSC Code:
12352200
PubChem Substance ID:
329817738
NACRES:
NA.77
MDL number:
MFCD00974506

Nom du produit

Mdivi-1, ≥98% (HPLC), powder

SMILES string

COc1cc(N2C(S)=Nc3ccccc3C2=O)c(Cl)cc1Cl

InChI

1S/C15H10Cl2N2O2S/c1-21-13-7-12(9(16)6-10(13)17)19-14(20)8-4-2-3-5-11(8)18-15(19)22/h2-7H,1H3,(H,18,22)

InChI key

NZJKEVWTYMOYOR-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: >20 mg/mL

shipped in

wet ice

storage temp.

−20°C

Quality Level

100

Catégories apparentées

Application

Mdivi-1 has been used:
  • in embryonic thoracic aorta A7r5 cells to inhibit cell migration and proliferation
  • in mitochondrial network reshaping and reactive oxygen species (ROS) production studies in oligodendrocyte precursor cells (OPCs)
  • to induce mitochondrial damage in lung fibroblasts

Biochem/physiol Actions

Mdivi-1 is a cell-permeable selective inhibitor of mitochondrial division DRP (dynamin-related GTPase) and inhibitor of the mitochondrial division dynamin (Dnm1). Mitochondrial fusion and division play important roles in the regulation of apoptosis. Mdivi-1 is the first selective inhibitor of mitochondrial division dynamins. In principle, Mdivi-1 represents a class of therapeutics for stroke, myocardial infarction, and neurodegenerative diseases.
Mdivi-1 is a selective inhibitor of mitochondrial division DRP (dynamin-related GTPase); inhibitor of the mitochondrial division dynamin (Dnm1).

Features and Benefits

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

General description

Mitochondrial Division Inhibitor 1 (Mdivi-1) is a quinazolinone derivative and is cell permeable. It traverses blood-brain barrier and elicits protective functionality in heart and brain ischemia-reperfusion injury.

Classe de stockage

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificats d'analyse (COA)

Lot/Batch Number
0000490644
0000209807
0000209807
0000167406
0000203464

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Consulter la Bibliothèque de documents

To mdivi-1 or not to mdivi-1: Is that the question?
Smith G and Gallo G
Developmental neurobiology, 77(11), 1260-1268 (2017)
Da Zhang et al.
PloS one, 13(5), e0197266-e0197266 (2018-05-17)
Hypoxia-mediated pancreatic beta cell death is one of the main causes of pancreatic beta celldeath, which leads to the loss of functional pancreatic beta cell mass and type 1 diabetes andtype 2 diabetes.However, the molecular mechanisms that control life and
The putative Drp1 inhibitor mdivi-1 is a reversible mitochondrial complex I inhibitor that modulates reactive oxygen species
Bordt EA, et al.
Developmental Cell, 40(6), 583-594 (2017)
Jia Sun et al.
The Journal of endocrinology (2019-01-09)
The molecular signaling mechanisms of Coenzyme Q10 (CoQ10) in diabetic nephropathy (DN) remain poorly understood. We verified that mitochondrial abnormalities, like defective mitophagy, the generation of mitochondrial reactive oxygen species (mtROS) and the reduction of mitochondrial membrane potential, occurred in
Impaired mitophagy leads to cigarette smoke stress-induced cellular senescence: implications for chronic obstructive pulmonary disease
Ahmad T, et al.
Faseb Journal, 29(7), 2912-2929 (2015)
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