M1787
Manganese(II) chloride solution
BioReagent, storage temp.:room temp, Molecular Biology
Synonyme(s) :
Manganese chlroide, Manganese(II) chloride, MnCl2
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A propos de cet article
Formule linéaire :
MnCl2
Numéro CAS:
Poids moléculaire :
125.84
NACRES:
NA.52
PubChem Substance ID:
UNSPSC Code:
12352302
MDL number:
Grade:
Molecular Biology
Form:
liquid
Service technique
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Molecular Biology
Quality Level
sterility
0.2 μm filtered
product line
BioReagent
form
liquid
concentration
1.00 M±0.01 M
cation traces
heavy metals (as Pb): ≤5 ppm
foreign activity
DNase, Exonuclease; NICKase, Endonuclease; and protease, none detected
storage temp.
room temp
SMILES string
Cl[Mn]Cl
InChI
1S/2ClH.Mn/h2*1H;/q;;+2/p-2
InChI key
GLFNIEUTAYBVOC-UHFFFAOYSA-L
General description
Manganese (II) chloride (MnCl2) might play a key role in integrin activation. Manganese is indispensable for brain function and is an essential cofactor for several key enzymes like superoxide dismutase and enzymes involved in neurotransmitter synthesis. Manganese can modulate iron and calcium homeostasis. Manganese is also used in the magnetic resonance imaging to increase contrast while examining neuronal connections and brain cytoarchitecture. High levels of manganese is toxic to central nervous system and causes Parkinson′s like symptoms called as manganism. MnCl2 has been used in reverse transcription reaction mix to enhance the template-switching efficiency.
MnCl2 solution is a source of manganese ions and has a variety of biological uses. In biochemistry, it can be used as a cofactor in restriction enzymes, such as BamH and EcoR V. In molecular biology, Mn2+ can be substituted for Mg2+ as a divalent metal ion to facilitate DNase I activity in presence of Ca2+.
Application
Manganese (II) chloride solution has been used:
- in manganese enhanced magnetic resonance imaging (MEMRI) to study neuronal disease and manganese toxicity
- in high ionic strength reaction mixture to determine RNA polymerase I and II activity
- in reverse transcription reaction mix as a source of Mn2+ ions
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Dam. 1 - STOT RE 2
target_organs
Brain
Classe de stockage
12 - Non Combustible Liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, multi-purpose combination respirator cartridge (US)
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Contenu apparenté
Product Information Sheet
Molecular Cloning: A Laboratory Manual
Sambrook, J. and Russel, D.W.
Molecular Cloning: A Laboratory Manual, 1, A4-A4 (2001)
In vitro Assessment of RNA Polymerase I Activity
Govoni M
Oncogene (2016)
Syndecan-1 regulates cell migration and fibronectin fibril assembly
Stepp MA, et al.
Experimental Cell Research, 316(14), 2322-2339 (2010)