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Merck

M4280

Anti-Mouse IgG (Fc specific) antibody produced in goat

2.0 mg/mL, affinity isolated antibody

Synonyme(s) :

Anti Mouse Fc Antibody, Anti Mouse Fc Antibody - Anti-Mouse IgG (Fc specific) antibody produced in goat

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.46
MDL number:

Nom du produit

Anti-Mouse IgG (Fc specific) antibody produced in goat, 2.0 mg/mL, affinity isolated antibody

biological source

goat

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

secondary antibodies

clone

polyclonal

concentration

2.0 mg/mL

technique(s)

indirect ELISA: 1:20,000

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

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Catégories apparentées

Application

Anti-Mouse IgG (Fc specific) antibody produced in goat has been used in:
  • enzyme-linked immunosorbent assay (ELISA)
  • flow cytometry
  • immunoprecipitation
  • immunoblotting

Biochem/physiol Actions

IgG antibody plays a crucial role in humoral immune responses such as complement activation, phagocytosis, placental transport and cell surface-receptor binding. The antigen binding activity is mediated by the variable Fab region of IgG antibodies, whereas the effector activities are stimulated by the Fc domain. Anti-mouse IgG (Fc specific) antibody can be used to detect the optimal capture agents.
Immunoglobulin G (IgG) participates in hypersensitivity type II and type III reactions. It mainly helps in immune defense. IgG helps in opsonization, complement fixation and antibody dependent cell mediated cytotoxicity.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Immunoglobulin G (IgG) belongs to the immunoglobulin family and is a widely expressed serum antibody. Immunoglobulins have two heavy chains and two light chains connected by a disulfide bond. It mainly helps in immune defense. It is a glycoprotein. IgG is a major class of immunoglobulin. Mouse consists of five immunoglobulin classes- IgM, IgG, IgA, IgD and IgE. Mouse IgG is further divided into five classes- IgG1, IgG2a, IgG2b and IgG3. IgG helps in opsonization, complement fixation and antibody dependent cell mediated cytotoxicity.

Immunogen

Fc fragment of IgG purified from mouse.

Other Notes

Antibody adsorbed with bovine, equine and human serum proteins.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Preparation Note

Adsorbed to reduce background staining with bovine, horse or human samples.

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Classe de stockage

12 - Non Combustible Liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable


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Consulter la Bibliothèque de documents

A genome-wide loss-of-function screen identifies SLC26A2 as a novel mediator of TRAIL resistance
Dimberg LY, et al.
Molecular Cancer Research, 15(4), 382-394 (2017)
NELF coordinates RNA polymerase II pausing, premature termination and chromatin remodeling to regulate HIV transcription
Natarajan M, et al.
The Journal of biological chemistry, jbc-M113 (2013)
T Groot Kormelink et al.
Allergy, 67(9), 1165-1172 (2012-07-07)
Free light chain (FLC) concentrations are demonstrated to be increased in different inflammatory disorders and are proposed to mediate mast cell-dependent immune responses. A role for mast cells is suggested in chronic rhinosinusitis with nasal polyposis (CRSwNP), which is characterized
Esmaeil Mortaz et al.
Journal of inflammation (London, England), 12, 21-21 (2015-04-14)
Sarcoidosis is a systemic disease of unknown etiology characterized histologically by the observation of non-caseating granulomas and several immunological abnormalities. Sarcoidosis is a multi-organ disorder which involves formation of granulomas in many tissues including the lungs (pulmonary) and others such
Lina Y Dimberg et al.
Molecular cancer research : MCR, 15(4), 382-394 (2017-01-22)
TRAIL is a potent death-inducing ligand that mediates apoptosis through the extrinsic pathway and serves as an important endogenous tumor suppressor mechanism. Because tumor cells are often killed by TRAIL and normal cells are not, drugs that activate the TRAIL

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