M7397
L-(−)-Malic acid
suitable for cell culture, BioReagent, suitable for insect cell culture
Synonyme(s) :
(S)-(−)-2-Hydroxysuccinic acid, L-Hydroxybutanedioic acid
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A propos de cet article
Formule linéaire :
HO2CCH2CH(OH)CO2H
Numéro CAS:
Poids moléculaire :
134.09
UNSPSC Code:
12352205
NACRES:
NA.75
PubChem Substance ID:
EC Number:
202-601-5
Beilstein/REAXYS Number:
1723541
MDL number:
Assay:
≥95% (titration)
Form:
powder
Service technique
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Laissez-nous vous aiderbiological source
microbial
Quality Level
product line
BioReagent
assay
≥95% (titration)
form
powder
technique(s)
cell culture | insect: suitable, cell culture | mammalian: suitable
mp
101-103 °C (lit.)
solubility
water: 100 mg/mL, clear to slightly hazy, colorless
SMILES string
O[C@@H](CC(O)=O)C(O)=O
InChI
1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/t2-/m0/s1
InChI key
BJEPYKJPYRNKOW-REOHCLBHSA-N
General description
Malic acid is used as a component of insect tissue culture. It is also useful as an acidulant in soft drinks, jams, fruit and vegetable juices.
Application
Malic acid has been used:
- to induce basal respiration in mitochondrial cell culture
- to measure the mitochondrial ETC (electron transport chain) activity
- as a component of mitochondrial substrate stock
Biochem/physiol Actions
Malic acid is a part of cellular metabolism. Its application is recognized in pharmaceutics. It is useful in the treatment of hepatic malfunctioning, effective against hyper-ammonemia. It is used as a part of amino acid infusion. Malic acid also serves as a nanomedicine in the treatment of brain neurological disorders. A TCA (Krebs cycle) intermediate and partner in the malic acid aspartate shuttle.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2
Classe de stockage
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Analysis of regional brain mitochondrial bioenergetics and susceptibility to mitochondrial inhibition utilizing a microplate based system
Sauerbeck A, et al.
Journal of Neuroscience Methods, 198(1), 36-43 (2011)
Continuous production of L-malic acid by immobilized Brevibacterium ammoniagenes cells
Yamamoto K, et al.
Europ. J. Appl. Microbiol. Biotechnol., 3(3), 169-183 (1976)
Invertebrate Tissue Culture, 11-11 (2012)