N1016
Nimesulide
Synonyme(s) :
N-(4-Nitro-2-phenoxyphenyl)methanesulfonamide
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A propos de cet article
Formule empirique (notation de Hill) :
C13H12N2O5S
Numéro CAS:
Poids moléculaire :
308.31
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
257-431-4
MDL number:
Service technique
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Laissez-nous vous aiderQuality Level
biological source
synthetic (organic)
assay
≥98% (TLC)
form
powder
solubility
ethanol: 50 mg/mL
storage temp.
2-8°C
SMILES string
CS(NC1=C(OC2=CC=CC=C2)C=C([N+]([O-])=O)C=C1)(=O)=O
InChI
1S/C13H12N2O5S/c1-21(18,19)14-12-8-7-10(15(16)17)9-13(12)20-11-5-3-2-4-6-11/h2-9,14H,1H3
InChI key
HYWYRSMBCFDLJT-UHFFFAOYSA-N
Gene Information
human ... ALB(213), PTGS1(5742), PTGS2(5743)
General description
Nimesulide, a nonsteroidal anti-inflammatory drug (NSAID) belongs to the sulfonanilide class.
Application
Nimesulide has been used as a component in the reaction mixture to determine the activity of cyclooxygenase (COX) in spleen of chickens.
Biochem/physiol Actions
Highly selective cyclooxygenase-2 inhibitor.
Nimesulide can be used as a substitute to other nonsteroidal anti-inflammatory drugs (NSAIDs) to treat pain and inflammation of osteoarthritis for a short period. It can perform anti-inflammatory, analgesic and antipyretic activities.
signalword
Danger
hcodes
pcodes
Hazard Classifications
Acute Tox. 3 Oral
Classe de stockage
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
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Nimesulide
Davis R and Brogden R N
Drugs, 48(3), 431-454 (1994)
Effects of dietary fish oil on NF
Yang X, et al.
The Journal of animal ecology, 20(3), 206-223 (2011)
Brijesh Kumar Singh et al.
PloS one, 7(4), e34200-e34200 (2012-04-18)
Nimesulide, an anti-inflammatory and analgesic drug, is reported to cause severe hepatotoxicity. In this study, molecular mechanisms involved in deranged oxidant-antioxidant homeostasis and mitochondrial dysfunction during nimesulide-induced hepatotoxicity and its attenuation by plant derived terpenes, camphene and geraniol has been