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Merck

N1142

Neomycin

solution, suitable for cell culture, BioReagent

Synonyme(s) :

Antibiotic 10676, Neomycin B

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A propos de cet article

UNSPSC Code:
12352207
PubChem Substance ID:
24897464
NACRES:
NA.76

Principaux documents

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Nom du produit

Neomycin solution, with 10 mg/mL neomycin in 0.9% NaCl, 0.1 μm filtered, BioReagent, suitable for cell culture

InChI

1S/C23H46N6O13/c24-2-7-13(32)15(34)10(28)21(37-7)40-18-6(27)1-5(26)12(31)20(18)42-23-17(36)19(9(4-30)39-23)41-22-11(29)16(35)14(33)8(3-25)38-22/h5-23,30-36H,1-4,24-29H2/t5-,6+,7-,8+,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23+/m1/s1

InChI key

PGBHMTALBVVCIT-VCIWKGPPSA-N

SMILES string

NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O)[C@H]2O[C@@H]3O[C@H](CO)[C@@H](O[C@H]4O[C@@H](CN)[C@@H](O)[C@H](O)[C@H]4N)[C@H]3O)[C@H](N)[C@@H](O)[C@@H]1O

biological source

Streptomyces fradiae

sterility

0.1 μm filtered

product line

BioReagent

form

liquid

potency

8-12 mg per mL

packaging

pkg of 20ML

concentration

10 mg/mL in 0.9% NaCl (neomycin)

technique(s)

cell culture | mammalian: suitable

impurities

endotoxin, tested

color

clear

UniProt accession no.

O14746

antibiotic activity spectrum

Gram-negative bacteria
Gram-positive bacteria

mode of action

protein synthesis | interferes

storage temp.

2-8°C

Quality Level

200

Gene Information

human ... TERT(7015)

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Catégories apparentées

Application

Neomycin solution has been used:
  • as a supplement of autoclaved acidified water for bone marrow transplantation
  • for the selection of stable clones
  • as a component of artificial sea water (ASWO) medium to remove bacteria from O. tauri cultures

Biochem/physiol Actions

Neomycin is an aminoglycoside antibiotic, produced by Streptomyces containing a minimum of 85% neomycin B. It acts as a selection agent for prokaryotic cells transformed using the neo selectable marker gene. Neomycin trisulfate is used to study the cytototoxic side effects of antibiotics, platelet-derived growth factor responses in certain fibroblasts and extraction of nuclear phosphatidylinositol 4,5-bisphosphate-interacting proteins. This product is recommended for use in cell culture applications at 5 mL/L.
Mode of action: This product acts by binding to the 30S and 50S subunits, causing miscoding and inhibiting initiation and elongation during protein synthesis. Neomycin also blocks voltage-sensitive Ca2+ channels without affecting the Na+/Ca2+ antiporter in neurons.
Antimicrobial spectrum: Neomycin acts against both gram-positive and gram-negative bacteria

Disclaimer

This solution is formulated to contain 10 mg/mL neomycin in 0.9% sodium chloride. It is stable at 37 °C for 5 days and should be otherwise stored at 2-8°C.

General description

Chemical structure: aminoglycoside

pictograms

Health hazard
GHS08

signalword

Danger

hcodes

H317,H334

Hazard Classifications

Resp. Sens. 1 - Skin Sens. 1

Classe de stockage

10 - Combustible liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

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Certificats d'analyse (COA)

Lot/Batch Number
0000475580
0000475580
0000421719
0000421721
0000421721

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Consulter la Bibliothèque de documents

Tudor Arvinte et al.
Journal of pharmaceutical and biomedical analysis, 175, 112742-112742 (2019-07-26)
The biosimilarity assessment of the physicochemical properties of high-concentration biopharmaceuticals is usually performed with measurements on diluted solutions, at concentrations below 1 mg/mL. In this study 13 orthogonal, spectroscopy and particle size determination methods were used to characterize the structure and
Long non-coding antisense RNA controls Uchl1 translation through an embedded SINEB2 repeat
Carrieri C, et al.
Nature, 491(7424), 454-454 (2012)
Metabolic profiling identifies trehalose as an abundant and diurnally fluctuating metabolite in the microalga Ostreococcus tauri
Hirth M, et al.
Metabolomics, 13(6), 68-68 (2017)
Tudor Arvinte et al.
Journal of pharmaceutical and biomedical analysis, 176, 112802-112802 (2019-08-26)
The physicochemical properties of Avastin® manufactured in the USA (Originator USA) and in Europe (Originator EU) and ABX-BEV, a bevacizumab biosimilar drug product candidate produced by Apobiologix Inc., were characterized at a clinically relevant concentration of 2 mg/mL following dilution of
Alexandria M Hudson et al.
Frontiers in cellular neuroscience, 14, 234-234 (2020-08-28)
Hearing loss is the third most common chronic health condition in the United States and largely results from damage to sensory hair cells. Major causes of hair cell damage include aging, noise exposure, and medications such as aminoglycoside antibiotics. Due
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