N149
Nimodipine
≥98% (HPLC), L-type Ca2+ channel antagonist, powder
Synonyme(s) :
1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-methoxyethyl 1-methylethyl ester, Isopropyl 2-methoxyethyl 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate
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A propos de cet article
Nom du produit
Nimodipine,
assay
≥98% (HPLC)
Quality Level
form
powder
color
off-white to yellow
solubility
methanol: 62.5 mg/mL, 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: insoluble, H2O: insoluble
originator
Bayer
SMILES string
COCCOC(=O)C1=C(C)NC(C)=C(C1c2cccc(c2)[N+]([O-])=O)C(=O)OC(C)C
InChI
1S/C21H26N2O7/c1-12(2)30-21(25)18-14(4)22-13(3)17(20(24)29-10-9-28-5)19(18)15-7-6-8-16(11-15)23(26)27/h6-8,11-12,19,22H,9-10H2,1-5H3
InChI key
UIAGMCDKSXEBJQ-UHFFFAOYSA-N
Gene Information
human ... ADORA3(140), CACNA1C(775), CACNA1D(776), CACNA1F(778), CACNA1S(779), CACNG1(786), NR3C2(4306)
rat ... Adora1(29290), Adora2a(25369)
Application
- as a L-type calcium channel (LTCC) inhibitor, to evaluate its neuroprotective activity in the vibrosections
- as a standard, in the enantioseparation of chiral drugs by high performance liquid chromatography (HPLC)
- in the pharmacological studies for the measurement of spine voltage escape
Biochem/physiol Actions
Features and Benefits
Disclaimer
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
Classe de stockage
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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