N4142

Anti-Neurofilament 200 antibody produced in rabbit

Name: Anti-Neurofilament 200 antibody produced in rabbit
Brand: SIGMA

IgG fraction of antiserum, buffered aqueous solution

Synonyme(s) :

NF200 Antibody - Anti-Neurofilament 200 antibody produced in rabbit, Nf200 Antibody, AntiNeurofilament heavy chain

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About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD02263444

Nom du produit

Anti-Neurofilament 200 antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution

biological source

rabbit

conjugate

unconjugated

antibody form

IgG fraction of antiserum

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 200 kDa

species reactivity

bovine, wide range

packaging

antibody small pack of 25 μL

enhanced validation

independent ( Antibodies)
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technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:80 using animal cerebellum sections
microarray: suitable
western blot: suitable

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Application

Anti-neurofilament 200 antibody produced in rabbit has been used for immunolabeling.
Anti-neurofilament 200 antibody produced in rabbit has been used:

for detection of neurofilaments using immunohistological staining
in human astrocytoma cell line
in post-mortem brain sections
in human cremaster muscles
for detection of neurofilaments by immunofluorescence staining in lumbar spinal cord sections of mice

Biochem/physiol Actions

Neurofilament 200 plays a vital role in cytoarchitecture organization. Downregulated expression of the gene has been observed in schizophrenia patients. Loss of gene expression is associated with the development of prostate carcinoma. Mutation in the gene leads to sporadic amyotrophic lateral sclerosis (ALS).
Neurofilament 200 assembly during development is critical for normal functioning of neuronal cells. Mutations in gene encoding neurofilaments is associated with neurological disorder called the Charcot–Marie–Tooth.

Shows a wide species cross-reactivity. Reacts with neurofilaments in the central and peripheral nervous system and localizes the neurofilament polypeptide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Neurofilament 200, also known as neurofilament heavy polypeptide (NEFH), is encoded by the gene mapped to human chromosome 22q12.2. The encoded protein has a molecular mass of 200kDa and belongs to the group of type IV intermediate filaments which are key constituents of the neuronal cytoskeleton. NEFH contains C-terminal motifs involved in the formation of sidearm projections which cross-link the neurofilaments.

Immunogen

Neurofilament 200 from bovine spinal cord.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Preparation Note

Store at -20°C. For continuous use, the product may be stored at 2-8°C for up to one month. For extended storage, solution may be frozen in working aliquots at –20°C. Repeated freezing and thawing is not recommended. If slight turbidity occurs upon prolonged storage, clarify by centrifugation before use.

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Classe de stockage

12 - Non Combustible Liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Control of neurulation by the nucleosome assembly protein-1-like 2.

Rogner UC, et al.

Nature Genetics, 25, 431-435 (2000)

Peripherin-mediated death of motor neurons rescued by overexpression of neurofilament NF-H proteins.

Beaulieu JM and Julien JP

Journal of Neurochemistry, 85(1), 248-256 (2003)

Hydrogen Peroxide-Induced Neurotoxicity in Cultured Cortical Cells Grown in SerumFree
and Serum-Containing Media

Ricart KC and Fiszman ML.

Neurochemical Research, 26, 801-808 (2001)

In vivo magnetic resonance imaging of ferritin-based reporter visualizes native neuroblast migration

Iordanova B and Ahrens ET.

Neuroimage, 59, 1004-1012 (2012)

Morphology and innervation of the human cremaster muscle in relation to its function.

Kayalioglu G, et al.

The Anatomical Record, 291(7), 790-796 (2008)

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Contenu apparenté

Data Sheet - N4142

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