N5751
Nω-Nitro-L-arginine methyl ester hydrochloride
≥97% (TLC), powder, nitric oxide production inhibitor
Synonyme(s) :
L-NAME HCl, L-NAME hydrochloride
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A propos de cet article
Formule empirique (notation de Hill) :
C7H15N5O4 · HCl
Numéro CAS:
Poids moléculaire :
269.69
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352209
EC Number:
257-116-1
MDL number:
Beilstein/REAXYS Number:
3744166
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Laissez-nous vous aiderNom du produit
Nω-Nitro-L-arginine methyl ester hydrochloride, ≥97% (TLC), powder
biological source
synthetic
Quality Level
assay
≥97% (TLC)
form
powder
color
white to off-white
mp
132 °C
solubility
H2O: 50 mg/mL
storage temp.
−20°C
SMILES string
Cl.COC(=O)[C@@H](N)CCCNC(=N)N[N+]([O-])=O
InChI
1S/C7H15N5O4.ClH/c1-16-6(13)5(8)3-2-4-10-7(9)11-12(14)15;/h5H,2-4,8H2,1H3,(H3,9,10,11);1H/t5-;/m0./s1
InChI key
QBNXAGZYLSRPJK-JEDNCBNOSA-N
Catégories apparentées
General description
Nω-Nitro-L-argininemethyl ester hydrochloride or L -NAME HCl, ananalog of arginine, inhibits NO production. It has multiple effects on thevascular system. Inhibits relaxation induced by acetylcholine and induces anincrease in arterial blood pressure. Abolishes lecithinized superoxidedismutase induced vasodilation when used to pretreat aortic ring preparationsof mice. Induces leukocyte adhesion and increases microvascular fluid andprotein fluxes and permeability. It has also been used in many studies oflearning and memory.
Application
Nω-Nitro-L-arginine methyl ester hydrochloride has been used:
- to study the effects of brain-derived neurotrophic factor against neurotoxicity in rat cortical neurons
- to study its effect on far-infrared (FIR) enhanced microcirculation of rat skin
- to study its effect on leptin-induced regulation of myokine fibronectin type III domain containing five/irisin in murine myocytes and fat cells
- to study its effect on the levels of arginine vasopressin and neuronal nitric oxide synthase mRNA levels in hypothalamic paraventricular nucleus and supraoptic nucleus of rat
Biochem/physiol Actions
Arginine analog that inhibits NO production.
Classe de stockage
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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P Kubes et al.
The American journal of physiology, 262(2 Pt 2), H611-H615 (1992-02-01)
We recently demonstrated that inhibitors of nitric oxide (NO) production cause a dramatic increase in leukocyte adherence and emigration in postcapillary venules. The objective of this study was to assess whether inhibition of NO production leads to vascular protein leakage
L B Zou et al.
Neuropharmacology, 37(3), 323-330 (1998-07-29)
We investigated the role of nitric oxide (NO) in learning and memory formation in a radial maze test, by using the NO synthase (NOS) inhibitors, NG-nitro-L-arginine methyl ester (L-NAME) and 7-nitroindazole (7-NI), and an NO precursor, L-arginine. Rats were trained
Anne-Clémence Vion et al.
Circulation research, 112(10), 1323-1333 (2013-03-29)
Endothelial activation and apoptosis release membrane-shed microparticles (EMP) that emerge as important biological effectors. Because laminar shear stress (SS) is a major physiological regulator of endothelial survival, we tested the hypothesis that SS regulates EMP release. EMP levels were quantified
Lisa Nguy et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 304(9), R744-R752 (2013-03-22)
Rats with adenine-induced chronic renal failure (A-CRF) develop metabolic and cardiovascular abnormalities resembling those in patients with chronic kidney disease. The aim of this study was to investigate the mechanisms of hypertension in this model and to assess aortic stiffness
Protective effects of brain-derived neurotrophic factor against neurotoxicity of 3-nitropropionic acid in rat cortical neurons.
Wu CL, et al.
Neurotoxicology, 30(4), 718-726 (2009)
Contenu apparenté
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