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Merck

N6383

Neurotensin

≥90% (HPLC), analgesia inducer, powder

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A propos de cet article

Formule empirique (notation de Hill) :
C78H121N21O20
Numéro CAS:
58889-67-1
Poids moléculaire :
1672.92
UNSPSC Code:
51111800
PubChem Substance ID:
329818664
NACRES:
NA.32
MDL number:
MFCD00076678

Principaux documents

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Nom du produit

Neurotensin, ≥90% (HPLC)

SMILES string

CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]3CCCN3C(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](Cc4ccc(O)cc4)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]5CCC(=O)N5)C(=O)N[C@@H](CC(C)C)C(O)=O

InChI

1S/C78H121N21O20/c1-7-43(6)63(73(115)96-57(76(118)119)37-42(4)5)97-70(112)55(39-45-21-25-47(101)26-22-45)95-72(114)59-18-13-35-99(59)75(117)52(16-11-33-86-78(83)84)90-64(106)48(15-10-32-85-77(81)82)89-71(113)58-17-12-34-98(58)74(116)51(14-8-9-31-79)91-69(111)56(40-60(80)102)94-66(108)50(28-30-62(104)105)88-68(110)54(38-44-19-23-46(100)24-20-44)93-67(109)53(36-41(2)3)92-65(107)49-27-29-61(103)87-49/h19-26,41-43,48-59,63,100-101H,7-18,27-40,79H2,1-6H3,(H2,80,102)(H,87,103)(H,88,110)(H,89,113)(H,90,106)(H,91,111)(H,92,107)(H,93,109)(H,94,108)(H,95,114)(H,96,115)(H,97,112)(H,104,105)(H,118,119)(H4,81,82,85)(H4,83,84,86)/t43-,48-,49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,63-/m0/s1

InChI key

PCJGZPGTCUMMOT-ISULXFBGSA-N

assay

≥90% (HPLC)

form

powder

UniProt accession no.

P30990

storage temp.

−20°C

Quality Level

200

Gene Information

human ... NTS(4922)

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Catégories apparentées

General description

Neurotensin (NT) is encoded by the gene mapped to human chromosome 12q21.31. The encoded protein is a tridecapeptide with pGlu–Leu–Tyr–Glu–Asn–Lys–Pro–Arg–Arg–Pro–Tyr–Ile–Leu–COOH amino acid sequence. NT is widely distributed in the gastrointestinal (GI) tract and central nervous system (CNS), but at high levels in hypothalamus, amygdala and nucleus accumbens as well as at low levels in peripheral blood.

Application

Neurotensin has been used as an external calibration reagent in spectrum calibration. It has also been used to evaluate the performance of online capillary electrophoresis to matrix-assisted laser desorption ionization (CE-MALDI).
Neurotensin has been used in apoptosis/ cell death assay and is used in:
  • matrix-assisted laser desorption/ionisation-time of flight (MALDI-TOF) mass spectrometry analysis

Biochem/physiol Actions

Neurotensin (NT) acts as an inducer for analgesia, hypothermia and hyperglycemia, and is an inhibitor of gastric motility. Plasma NT levels are high in children with Prader–Willi syndrome (PWS). NT secreted from small cell lung cancer cells might have a regulatory action in this disease. It has been implicated in regulation of gastric system and inflammatory processes in the lung. In addition, NT also regulates immune response by stimulating cytokine release and chemotaxis on interaction with leukocytes, peritoneal mast cells and dendritic cells. NT present in gastrointestinal (GI) tract plays a vital role in various processes such as stimulation of pancreatic and biliary secretion and enhances growth of various normal tissues. It is involved downstream of Wnt/β-catenin signaling pathway and stimulates the growth of neuroendocrine tumor cells.

Classe de stockage

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificats d'analyse (COA)

Lot/Batch Number
0000523215
0000523215
0000528944
0000528944
0000514040

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Neurotensin modulates the migratory and inflammatory response of macrophages under hyperglycemic conditions.
Moura LI
BioMed Research International, 2013:941764 (2013)
ProNGF mediates death of Natural Killer cells through activation of the p75NTR-sortilin complex.
Rogers ML
Journal of Neuroimmunology, 226(1-2), 93-103 (2010)
Online CE-MALDI-TOF MS Using a Rotating Ball Interface
Musyimi HK, et al.
Analytical Chemistry, 76(19), 5968-5973 (2004)
Daniel J Scott et al.
Biochimica et biophysica acta, 1838(11), 2817-2824 (2014-07-30)
The largest single class of drug targets is the G protein-coupled receptor (GPCR) family. Modern high-throughput methods for drug discovery require working with pure protein, but this has been a challenge for GPCRs, and thus the success of screening campaigns
Autohydrolysis of a partially cyclized mu/nu-carrageenan and structural elucidation of the oligosaccharides by chemical analysis, NMR spectroscopy and UV-MALDI mass spectrometry
Ciancia M, et al.
ARKIVOC (Gainesville, FL, United States), 12, 319-331 (2005)
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