P215

PD 98,059

Name: PD 98,059
Brand: SIGMA

MAPKK inhibitor, solid

Synonyme(s) :

2-(2-Amino-3-methoxyphenyl)-4H-1-benzopyran-4-one, PD98059

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About This Item

Formule empirique (notation de Hill) :

C₁₆H₁₃NO₃

Numéro CAS:

167869-21-8

Poids moléculaire :

267.28

UNSPSC Code:

12352200

PubChem Substance ID:

24278666

NACRES:

NA.77

MDL number:

MFCD00671789

Nom du produit

PD 98,059, solid

SMILES string

COc1cccc(c1N)C2=CC(=O)c3ccccc3O2

InChI

1S/C16H13NO3/c1-19-14-8-4-6-11(16(14)17)15-9-12(18)10-5-2-3-7-13(10)20-15/h2-9H,17H2,1H3

InChI key

QFWCYNPOPKQOKV-UHFFFAOYSA-N

form

solid

color

yellow

solubility

DMSO: 10 mg/mL, clear

storage temp.

−20°C

Quality Level

100

Gene Information

human ... MAP2K1(5604), MAP2K2(5605), MAP2K3(5606), MAP2K4(6416), MAP2K5(5607), MAP2K6(5608), MAP2K7(5609), MAP3K1(4214), RAF1(5894)

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Catégories apparentées

Bioactive Small Molecule Inhibitors

Bioactive Small Molecules

Application

PD 98,059 has been used:

in growth medium as a mitogen-activated protein (MAP) kinase inhibitor, in order to study the secondary messengers involved in the effect of D1-like receptors
in calcium-free RPMI (Roswell park memorial institute)-1640 medium to study its effect on inflammation, proliferation and differentiation in human epidermal keratinocyte cell line in conjunction of cystic fibrosis transmembrane conductance regulator (CFTR) knockdown
in culture medium for cell migration assay

Biochem/physiol Actions

PD 98,059 is a flavonoid and specific inhibitor of mitogen-activated protein kinase kinase (MAPKK). In mice, PD 98,059 helps to block zymosan stimulated organ dysfunction syndrome and non-septic shock. It is known to inhibit in vitro hypertrophy. PD 98,059 also induces cartilage formation in mesenchymal stromal cells.

Features and Benefits

This compound is featured on the MAPKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Legal Information

Sold with permission of Warner Lambert Company.

Classe de stockage

11 - Combustible Solids

wgk

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Consulter la Bibliothèque de documents

PD98059 is an equipotent antagonist of the aryl hydrocarbon receptor and inhibitor of mitogen-activated protein kinase kinase

Reiners JJ, et al.

Molecular Pharmacology, 53(3), 438-445 (1998)

Extracellular Matrix Proteins: Advances in Research and Application (2012)

Loss of imprinting mutations define both distinct and overlapping roles for misexpression of IGF2 and of H19 lncRNA.

Ki-Sun Park et al.

Nucleic acids research, 45(22), 12766-12779 (2017-12-16)

Imprinted genes occur in discrete clusters that are coordinately regulated by shared DNA elements called Imprinting Control Regions. H19 and Igf2 are linked imprinted genes that play critical roles in development. Loss of imprinting (LOI) at the IGF2/H19 locus on

Epidermal CFTR suppresses MAPK/NF-kappaB to promote cutaneous wound healing

Chen J

Cellular Physiology and Biochemistry, 39(6), 2262-2274 (2016)

D1-like receptors inhibit insulin-induced vascular smooth muscle cell proliferation via down-regulation of insulin receptor expression

Zeng C, et al.

Journal of Hypertension, 27(5), 1033-1033 (2009)

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Contenu apparenté

The Effective Use of Protein Kinase Inhibitors

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